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Special Issue "Methicillin-Resistant Staphylococci and Macrococci at the Interface of Human and Animal Health"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 31 August 2019

Special Issue Editor

Guest Editor
Prof. Dr. Karsten Becker

University Hospital of Münster, Institute of Medical Microbiology, Domagkstr. 10, 48149 Münster, Germany
Website | E-Mail
Phone: +49 (0)251 83 55375

Special Issue Information

Dear Colleagues,

The global importance of methicillin-resistant Staphylococcus aureus (MRSA) strains on human and animal health continues, even considering decreasing MRSA rates in some parts of the world. Subsequent to the emergence of hospital- and community-associated MRSA, livestock-associated MRSA and MRSA of different clonal lineages became an additional threat to human and animal health, contributing significantly to morbidity, mortality and socio-economic costs.

However, many aspects of their genetic basis, origin, distribution, transmission and introduction into the health care systems are still poorly understood. The enormous diversity of the SCCmec as a mobile genetic element harboring the methicillin resistance-encoding genes and other genes mediating resistance towards antibiotics, heavy metals and metalloids reflects the flexibility of staphylococci and their relatives, the macrococci, to resist the selection pressures occurring in their environment. The recent expansion of the mec “alphabet” by the detection of the mecC, mecB and mecD genes as well as the identification of plasmid-borne methicillin resistance in macrococci and staphylococci is additionally challenging routine diagnostics as well as epidemiological studies. Moreover, the impact of coagulase-negative staphylococci and coagulase-positive non-S. aureus species as well as the role of macrococci as source for methicillin resistance-encoding genetic elements in S. aureus are only scantily investigated.

Focusing on methicillin resistance in staphylococci and macrococci, this Special Issue aims to characterize basic, epidemiological, ecological and medical aspects on the interface between animal keeping, wildlife and putative other niches on one hand and the human and animal health on the other. In particular, submissions that specifically address the One World—One Health concept in this field, are welcome.

Prof. Dr. Karsten Becker
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Methicillin resistance
  • Oxacillin resistance
  • Betalactam resistance
  • Staphylococcus
  • Macrococcus
  • One Health
  • Husbandry
  • Livestock
  • Health
  • Epidemiology

Published Papers (1 paper)

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Research

Open AccessArticle
Nasal Colonization of Humans with Occupational Exposure to Raw Meat and to Raw Meat Products with Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus
Received: 6 March 2019 / Revised: 25 March 2019 / Accepted: 28 March 2019 / Published: 30 March 2019
PDF Full-text (261 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is widely disseminated as a nasal colonizer of conventionally raised livestock and of humans subjected to occupational exposure. Reports on contamination of raw meat raise the question as to whether occupationally exposed food handlers are at particular risk [...] Read more.
Livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) is widely disseminated as a nasal colonizer of conventionally raised livestock and of humans subjected to occupational exposure. Reports on contamination of raw meat raise the question as to whether occupationally exposed food handlers are at particular risk of nasal colonization by LA-MRSA. Here, we report the results from a cross-sectional study on nasal S. aureus/MRSA colonization of butchers, meat sellers, and cooks in Germany. We sampled 286 butchers and meat sellers in 26 butcheries and 319 cooks handling meat in 16 professional canteen kitchens. Swabs were processed on both blood agar plates and MRSA-selective plates. MRSA were confirmed by PCR for mec genes and by broth microdilution. All isolates were subjected to molecular typing. PCR for markers useful to differentiate human-adapted and animal-adapted subpopulations was performed due to the presence of clonal complexes known to occur in both livestock and humans (CC5, CC7, CC8, CC9, and CC398). Only two participants (0.33%) were colonized by MRSA (Hospital-associated MRSA ST22). Nasal colonization by methicillin-susceptible S. aureus (MSSA) was detected in 16.6% of cooks and in 26.2% of butchers and meat sellers. Among 16 of the isolates attributed to CC7, three were negative for the immune evasion gene cluster, suggesting an animal origin. Isolates attributed to CC5, CC8, and CC398 were negative for markers typical of animal-adapted subpopulations. The occupational handling of raw meat and raw meat products was not associated with nasal colonization by LA-MRSA. Full article
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