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Special Issue "Pathogenesis of Hemolytic Uremic Syndrome Caused by Shiga Toxin-Producing Escherichia coli Infections"
Deadline for manuscript submissions: 30 November 2019.
Human infections by Shiga toxin-producing Escherichia coli (STEC) cause severe and life-threatening diseases. These powerful pathogens are capable of elaborating a wide array of virulence factors which often overwhelm the host defense system. In particular, the exotoxins produced by these pathogenic E. coli strains, namely Shiga toxins, are the key bacterial factors responsible for hemolytic uremic syndrome (HUS), the main cause of acute renal failure in early childhood.
The pathogenesis of HUS is puzzling and not completely understood, despite a great deal of investigation. Toxins target host endothelial cells in the kidney and brain during the ultimate toxemic phase, culminating in HUS. However, a plethora of complex, concurrent and interactive phenomena occur during precocious toxemia when Shiga toxins interact with numerous blood components (neutrophils, monocytes, platelets, erythrocytes, human serum amyloid protein, complement factor H, and Toll-like receptor 4). The formation of platelet–leukocyte aggregates, the release of extracellular vesicles containing HUS-triggering pathogenic factors and the activation of complement system are well known consequences.
This Special Issue is aimed at focusing on all aspects of the interaction of Shiga toxins with host cell and/or molecules involved in the pathogenesis of STEC-induced HUS. The various papers dealing with specific arguments are expected to bring renewed insight on focalized topics, fostering our understanding of the general picture, as well as the single details of a canvas unveil their message only when they are considered in the general context.
Prof. Maurizio Brigotti
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Hemolytic uremic syndrome
- pathogen-host interactions
- Shiga toxins
- Shiga toxin-producing Escherichia coli
- STEC infections