Mycotoxins Exposure and Impact on Human and Animal Health

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 1007

Special Issue Editor


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Guest Editor
National Veterinary School of Toulouse, Université de Toulouse, ENVT, F-31076 Toulouse, France
Interests: mycotoxins; contaminants; animal toxicology; analytical toxicology; oxidative stress; sphingolipids; toxicokinetics; metabolism of toxic substances; drug-metabolizing enzymes
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Special Issue Information

Dear Colleagues,

The contamination of food and feed by toxigenic moulds has been a worrying problem for human and animal health for many years. Climate change, societal issues, and the development of new molecules capable of reducing mycotoxin toxicity, as well as the increase in knowledge through the identification of emerging mycotoxins and interactions between compounds or better characterisation of the toxic effects of mycotoxins and their biomarkers, make a Special Issue of Toxins on "Mycotoxins Exposure and Impact on Human and Animal Health" particularly justified in 2025.

The aim of this Special Issue is to present new knowledge on "One Health", with a particular focus on data generated under realistic exposure conditions. Manuscripts on the following topics are particularly welcome:

(a) The effects of emerging mycotoxins for which no maximum levels have been recommended for human or animal consumption;

(b) The effects of mycotoxins in mixtures and any studies to better characterise synergies, antagonisms, additive effects or indifferences between mycotoxins;

(c) The effects of non-mycotoxic factors, whether additives intentionally added to feed or contaminants and pathologies likely to modulate the health effects of mycotoxins;

(d) Biomarkers to help elucidate mycotoxin exposure and effects in humans and animals;

(e) Literature reviews, especially those that provide comparative insights into the "One Health" issue.

Purely mechanistic studies conducted at unrealistic exposure levels are not included in the objectives of this Special Issue, unless they provide mechanistic insight into a specific biological effect that is clearly explained in the introduction of the manuscript. Similarly, studies targeting mycotoxin synthesis pathways are not included in the objectives of this Special Issue.

Prof. Dr. Philippe Guerre
Guest Editor

Manuscript Submission Information

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Keywords

  • mycotoxins
  • multiple contamination
  • exposure
  • human health
  • animal health
  • toxicity
  • biomarker
  • interaction
  • feed additive

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Published Papers (1 paper)

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Research

23 pages, 2779 KiB  
Article
Biomarkers of Fumonisin Exposure in Pigs Fed the Maximum Recommended Level in Europe
by Elodie Lassallette, Alix Pierron, Didier Tardieu, Solène Reymondaud, Marie Gallissot, Maria Angeles Rodriguez, Pi Nyvall Collén, Olivier Roy and Philippe Guerre
Toxins 2025, 17(2), 69; https://doi.org/10.3390/toxins17020069 - 4 Feb 2025
Viewed by 781
Abstract
This study investigated biomarkers of fumonisin exposure in pigs fed diets contaminated with fumonisins at the European Union’s maximum recommended level. Pigs were assigned to either a fumonisin (FB) diet or a fumonisin plus AlgoClay (FB + AC) diet for durations of 4, [...] Read more.
This study investigated biomarkers of fumonisin exposure in pigs fed diets contaminated with fumonisins at the European Union’s maximum recommended level. Pigs were assigned to either a fumonisin (FB) diet or a fumonisin plus AlgoClay (FB + AC) diet for durations of 4, 9, and 14 days. At 14 days, the plasma Sa1P:So1P ratio increased in pigs fed the FB diet, while the Sa:So ratio remained unchanged. In the liver, FB1 was detected at four days of exposure, with the concentration tending to increase through day 14. The Sa:So and C22-24:C16 ratios of 18:1-, 18:2-, and m18:1-ceramides were elevated at 9 and 14 days, respectively. In the kidneys, FB1 was only detectable at 14 days, and the Sa:So and C22-24:C16 ratios of 18:1-ceramides were increased. In both the liver and kidneys, the increase in the C22-24:C16 ratio was attributed to a reduction of C16 ceramides. In the lungs, no FB1 was detected; however, the Sa:So and Sa1P:So1P ratios increased, and C16 ceramide concentrations decreased at 14 days. Feeding the pigs the FB + AC diet resulted in a reduction of the FB1 tissue-to-feed ratio in the liver and kidneys but did not affect the Sa:So or Sa1P:So1P ratios. Interestingly, the decreases in C16 ceramides observed in the FB diet group were no longer detectable in the FB + AC group. Overall, these findings highlight the complexity of the relationship between FB1 tissue concentrations and sphingolipid changes, suggesting that a comprehensive analysis of multiple biomarkers is required to fully understand fumonisin’s effects. Full article
(This article belongs to the Special Issue Mycotoxins Exposure and Impact on Human and Animal Health)
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