Neurotoxicity and Health Risks of Freshwater and Marine Toxin Exposure

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Marine and Freshwater Toxins".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1397

Special Issue Editors


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Guest Editor
Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, C/ Profesor García González 2, 41012 Seville, Spain
Interests: toxicology; food safety; cyanotoxins; microcystins; cylindrospermopsin; UPLC-MS/MS analyses; method validation; neurotoxicity; bioaccessibility
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Area of Toxicology, Faculty of Pharmacy, Universidad de Sevilla, 41012 Seville, Spain
Interests: toxicology; genotoxicity; cylindrospermopsin; microcystins; in vivo; in vitro; food safety; toxicological evaluation; method validation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The global rise in harmful algal blooms (HABs) poses a growing threat to both human health and the environment, and predictions indicate that the occurrence, frequency and severity of HABs are expected to escalate with ongoing climate changes. They can cause poisoning outbreaks in aquatic organisms, including seafood, due to the release of toxic metabolites, such as cyanotoxins. This represents a threat to consumers’ health, as aquatic organisms can accumulate these toxins throughout the food chain. This Special Issue is dedicated to gathering new research or review articles related to the neurotoxicity of freshwater and marine toxins, as well as health consequences of the toxins produced during bloom events. Going beyond their main toxicity pathways and also focusing on ecologically relevant model organisms. Moreover, contributions to the knowledge of neurotoxins emerged from OMICS (genomics, transcriptomics, proteomics and metabolomics) are also welcome in this Special Issue, as well as regulatory approaches worldwide and (eco)toxicity data. Another important aspect of interest is the validation of robust analytical methods for the determination of these toxins in waters and contaminated food. All contributions addressing the data gaps in the mentioned aspects are welcome in this Special Issue.

Dr. Remedios Guzmán-Guillén
Dr. Leticia Diez-Quijada Jiménez
Guest Editors

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Keywords

  • neurotoxicity
  • freshwater toxins
  • marine toxins
  • anatoxins
  • saxitoxins
  • BMAA
  • cylindrospermopsin
  • domoic acid
  • risk assessment
  • analytics

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Published Papers (1 paper)

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Research

22 pages, 5060 KiB  
Article
Phylogenetic and Autecology Characteristics of Five Potentially Harmful Dinoflagellate Alexandrium Species (Dinophyceae, Gonyaulacales, Pyrocystaceae) in Tropical Waters: A. affine, A. fraterculus, A. leei, A. pseudogonyaulax, and A. tamiyavanichii
by Lam Nguyen-Ngoc, Dang-Minh Luat, H. Doan-Nhu, H. M. Pham, B. Krock, N. D. Huynh-Thi, L. V. Tran-Thi, M. H. Tran-Thi, Anh H. Pham, V. Nguyen-Tam, T. T. Nhan-Luu and H. H. Do
Toxins 2025, 17(2), 81; https://doi.org/10.3390/toxins17020081 - 10 Feb 2025
Viewed by 950
Abstract
Five species of Alexandrium (A. affine, A. fraterculus, A. leei, A. pseudogonyaulax, and A. tamiyavanichii) are commonly found in Vietnamese waters. They were distinguished based on their apical pore complex (A.P.C), precingular first plate [...] Read more.
Five species of Alexandrium (A. affine, A. fraterculus, A. leei, A. pseudogonyaulax, and A. tamiyavanichii) are commonly found in Vietnamese waters. They were distinguished based on their apical pore complex (A.P.C), precingular first plate (1′), ventral pore (Vp), and sulcal platelets. A genetic analysis was conducted using nuclear rDNA sequences of ITS and LSU (D1–D3, D8–D10). The growth rates of A. fraterculus, A. leei, A. tamiyavanichii, and A. pseudogonyaulax were quite similar. Specifically, these four species had the highest growth rates at two temperature levels of 24 °C and 27 °C, at salinities ranging from 25 psu to 35 psu. Furthermore, these species were able to adapt to a low salinity of 20 psu at temperatures from 18 °C to 27 °C. No Paralytic Shellfish Toxins (PSTs) were found in the two Alexandrium affine strains, VINVN01-1 and VINVN01-2. The detection limit for PSTs ranged from 0.45 to 15.5 fg cell−1, depending on the molecular response and available biomass. Full article
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