Bacillus anthracis Toxins
A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".
Deadline for manuscript submissions: closed (18 August 2023) | Viewed by 2290
Special Issue Editor
Interests: Bacillus anthracis toxins
Special Issue Information
Dear Colleagues,
Anthrax is a life-threatening disease caused by an infection with Bacillus anthracis. The pXO1 virulence plasmid of B. anthracis expresses a binary anthrax toxin comprising a protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF). PA binds surface receptors on the host cells, mediating the translocation of the enzymatic moieties into the cytoplasm of the host cells. LF disrupts critical cellular signaling pathways via its zinc-dependent metalloprotease activity, which specifically cleaves mitogen-activated protein kinases, NACHT leucine-rich repeat protein 1 (NLRP1) and the regulatory subunits of phosphoinositide-3 kinase. EF is a Ca2+ and calmodulin-dependent adenylate cyclase that increases the level of cAMP in the host cell, disrupting water homeostasis, intracellular signaling pathways and macrophage function. This Special Issue of Toxins aims to provide a scientific platform for scientists performing fundamental, applied and translational research related to the Bacillus anthracis toxins. This Special Issue will include original studies, reviews and method papers on all research areas of the Bacillus anthracis toxins.
Dr. Weiming Ouyang
Guest Editor
Manuscript Submission Information
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Keywords
- anthrax
- lethal toxin
- edema toxin
- MAPK
- MKK
- NLRP1
- PI-3K
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