Special Issue "Bacillus anthracis Toxins"
Deadline for manuscript submissions: closed (18 August 2023) | Viewed by 518
Anthrax is a life-threatening disease caused by an infection with Bacillus anthracis. The pXO1 virulence plasmid of B. anthracis expresses a binary anthrax toxin comprising a protective antigen (PA) and two enzymatic moieties, edema factor (EF) and lethal factor (LF). PA binds surface receptors on the host cells, mediating the translocation of the enzymatic moieties into the cytoplasm of the host cells. LF disrupts critical cellular signaling pathways via its zinc-dependent metalloprotease activity, which specifically cleaves mitogen-activated protein kinases, NACHT leucine-rich repeat protein 1 (NLRP1) and the regulatory subunits of phosphoinositide-3 kinase. EF is a Ca2+ and calmodulin-dependent adenylate cyclase that increases the level of cAMP in the host cell, disrupting water homeostasis, intracellular signaling pathways and macrophage function. This Special Issue of Toxins aims to provide a scientific platform for scientists performing fundamental, applied and translational research related to the Bacillus anthracis toxins. This Special Issue will include original studies, reviews and method papers on all research areas of the Bacillus anthracis toxins.
Dr. Weiming Ouyang
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- lethal toxin
- edema toxin