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Tables of Toxicity of Botulinum and Tetanus Neurotoxins

Department of Biomedical Sciences, University of Padova, Via Ugo Bassi n. 58/B, 35121 Padova, Italy
Institute for Neuroscience, National Research Council, Via Ugo Bassi n. 58/B, 35121 Padova, Italy
Author to whom correspondence should be addressed.
Toxins 2019, 11(12), 686; (registering DOI)
Received: 8 October 2019 / Revised: 18 November 2019 / Accepted: 19 November 2019 / Published: 22 November 2019
(This article belongs to the Special Issue Characterization and Quantitative Analysis of Botulinum Neurotoxin)
Tetanus and botulinum neurotoxins are the most poisonous substances known, so much so as to be considered for a possible terrorist use. At the same time, botulinum neurotoxin type A1 is successfully used to treat a variety of human syndromes characterized by hyperactive cholinergic nerve terminals. The extreme toxicity of these neurotoxins is due to their neurospecificity and to their metalloprotease activity, which results in the deadly paralysis of tetanus and botulism. Recently, many novel botulinum neurotoxins and some botulinum-like toxins have been discovered. This large number of toxins differs in terms of toxicity and biological activity, providing a potential goldmine for novel therapeutics and for new molecular tools to dissect vesicular trafficking, fusion, and exocytosis. The scattered data on toxicity present in the literature require a systematic organization to be usable by scientists and clinicians. We have assembled here the data available in the literature on the toxicity of these toxins in different animal species. The internal comparison of these data provides insights on the biological activity of these toxins. View Full-Text
Keywords: botulinum neurotoxin; tetanus neurotoxin; botulism; tetanus; toxicity; lethal dose botulinum neurotoxin; tetanus neurotoxin; botulism; tetanus; toxicity; lethal dose
MDPI and ACS Style

Rossetto, O.; Montecucco, C. Tables of Toxicity of Botulinum and Tetanus Neurotoxins. Toxins 2019, 11, 686.

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