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Recent Advances of Detection, Health Intervention Treatment and Drug Development of Mycotoxins in Food and Feed

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A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 8035

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Special Issue Editors

Prof. Dr. Liang Ma

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Guest Editor

College of Food Science, Southwest University, Chongqing 400715, China
Interests: mycotoxins; fast detection; sensor; toxicity; interaction between mycotoxins and food matrix; detoxification of mycotoxins; hidden mycotoxins; prevention and control; food safety
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Jianping Xie

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Guest Editor

School of Life Sciences, Southwest University, Chongqing 400715, China
Interests: medical and health care; microbiology & immunology; mycobacterium tuberculosis; pathogenic bacterium; new vaccines/drugs; nutrition intervention

Special Issue Information

Dear colleagues,

Mycotoxins are natural substances that occur as a secondary product of the development of parasitic fungi. Most of mycotoxins are cytotoxic, even teratogenic and mutagenic, which poses significant risks to food safety and human health. Moreover, “modified mycotoxins” and “hidden mycotoxins” has more or less toxic than the original mycotoxins. To control and reduce the economical and health impacts of mycotoxins, we need to better develop foodborne active ingredients or drug from food materials such as foodborne plants and animals, and to identify mechanisms able to confer health intervention treatment and drug development to mycotoxin effects. Detection methods and control technology, meanwhile, confronted with great challenge in sensitively monitoring and detecting different type mycotoxins. To enhance the sensitivity and selectivity of detection methods, nanomaterials, such as graphene, metal nanoparticle, metal nanocluster, quantum dot, upconversion nanoparticles etc., and signal enhancement or amplification strategies could be introduced to construct the sensing and testing system. The Special issue is focused on the recent advances and new perspectives in detection, health Intervention treatment even drug development of Mycotoxins in Food and Feed.

Prof. Dr. Liang Ma
Prof. Dr. Jianping Xie
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

Mycotoxins
Detection
Signal enhancement or amplification strategies
Nanomaterials
Food matrix
Food materials
Nutrition intervention
Drug development

Published Papers (3 papers)

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Research

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13 pages, 2250 KiB

Open AccessArticle

Development of a Novel Magnetic-Bead-Based Automated Strategy for Efficient and Low-Cost Sample Preparation for Ochratoxin A Detection Using Mycotoxin–Albumin Interaction

by Jin Ye, Hui Bao, Mengyao Zheng, Hongmei Liu, Jinnan Chen, Songxue Wang, Haihua Ma and Yuan Zhang

Toxins 2023, 15(4), 270; https://doi.org/10.3390/toxins15040270 - 5 Apr 2023

Cited by 2 | Viewed by 1384

Abstract

The mycotoxin ochratoxin A (OTA) is toxic to humans and frequently contaminates wine and beer. Antibodies are essential recognition probes for the detection of OTA. However, they have several drawbacks, such as high costs and difficulty in preparation. In this study, a novel magnetic-bead-based automated strategy for efficient and low-cost OTA sample preparation was developed. Human serum albumin, which is an economical and stable receptor based on the mycotoxin–albumin interaction, was adapted and validated to replace conventional antibodies to capture OTA in the sample. Ultra-performance liquid chromatography–fluorescence detection was used in combination with this preparation method for efficient detection. The effects of different conditions on this method were investigated. The recovery of OTA samples spiked at three different concentrations ranged from 91.2% to 102.1%, and the relative standard deviations (RSDs) were 1.2%–8.2% in wine and beer. For red wine and beer samples, the LODs were 0.37 and 0.15 µg/L, respectively. This reliable method overcomes the drawbacks of conventional methods and offers significant application prospects. Full article

(This article belongs to the Special Issue Recent Advances of Detection, Health Intervention Treatment and Drug Development of Mycotoxins in Food and Feed)

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13 pages, 5473 KiB

Open AccessArticle

Study of Competitive Displacement of Curcumin on α-zearalenol Binding to Human Serum Albumin Complex Using Fluorescence Spectroscopy

by Yifang Li, Hongxia Tan, Hongyuan Zhou, Ting Guo, Ying Zhou, Yuhao Zhang, Xiaozhu Liu and Liang Ma

Toxins 2022, 14(9), 604; https://doi.org/10.3390/toxins14090604 - 31 Aug 2022

Cited by 3 | Viewed by 1636

Abstract

α-zearalenol (α-ZOL) is a mycotoxin with a strong estrogen effect that affects the synthesis and secretion of sex hormones and is transported to target organs through human serum albumin (HSA). Additionally, it has been reported that curcumin can also bind to HSA with high affinity at the same binding site as α-ZOL. Additionally, several studies reported that reducing the bound fraction of α-ZOL contributes to speeding up the elimination rate of α-ZOL to reduce its hazard to organs. Therefore, to explore the influence of a nutrition intervention with curcumin on α-ZOL effects, the competitive displacement of α-ZOL from HSA by curcumin was investigated using spectroscopic techniques, ultrafiltration techniques and HPLC methods. Results show that curcumin and α-ZOL share the same binding site (subdomain IIA) on HSA, and curcumin binds to HSA with a binding constant of 1.12 × 10⁵ M⁻¹, which is higher than that of α-ZOL (3.98 × 10⁴ M⁻¹). Ultrafiltration studies demonstrated that curcumin could displace α-ZOL from HSA to reduce α-ZOL’s binding fraction. Synchronous fluorescence spectroscopy revealed that curcumin could reduce the hydrophobicity of the microenvironment of an HSA–α-ZOL complex. This study is of great significance for applying curcumin and other highly active foodborne components to interfere with the toxicokinetics of α-ZOL and reduce its risk of its exposure. Full article

(This article belongs to the Special Issue Recent Advances of Detection, Health Intervention Treatment and Drug Development of Mycotoxins in Food and Feed)

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Review

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41 pages, 1727 KiB

Open AccessReview

Mycotoxins in Cereal-Based Products and Their Impacts on the Health of Humans, Livestock Animals and Pets

by Jianmei Yu and Ivana Ramos Pedroso

Toxins 2023, 15(8), 480; https://doi.org/10.3390/toxins15080480 - 28 Jul 2023

Cited by 11 | Viewed by 4608

Abstract

Cereal grains are the most important food staples for human beings and livestock animals. They can be processed into various types of food and feed products such as bread, pasta, breakfast cereals, cake, snacks, beer, complete feed, and pet foods. However, cereal grains are vulnerable to the contamination of soil microorganisms, particularly molds. The toxigenic fungi/molds not only cause quality deterioration and grain loss, but also produce toxic secondary metabolites, mycotoxins, which can cause acute toxicity, death, and chronic diseases such as cancer, immunity suppression, growth impairment, and neural tube defects in humans, livestock animals and pets. To protect human beings and animals from these health risks, many countries have established/adopted regulations to limit exposure to mycotoxins. The purpose of this review is to update the evidence regarding the occurrence and co-occurrence of mycotoxins in cereal grains and cereal-derived food and feed products and their health impacts on human beings, livestock animals and pets. The effort for safe food and feed supplies including prevention technologies, detoxification technologies/methods and up-to-date regulation limits of frequently detected mycotoxins in cereal grains for food and feed in major cereal-producing countries are also provided. Some important areas worthy of further investigation are proposed. Full article

(This article belongs to the Special Issue Recent Advances of Detection, Health Intervention Treatment and Drug Development of Mycotoxins in Food and Feed)

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