Special Issue "Polyhalogenated Aromatic Hydrocarbons"
A special issue of Toxics (ISSN 2305-6304).
Deadline for manuscript submissions: closed (30 September 2018)
Polyhalogenated aromatic hydrocarbons are planar polycyclic organic compounds with various numbers of halogen atoms, mostly chlorine. Among them, we find the so-called dioxin-like molecules, i.e., polychlorinated (i) dibenzodioxins (PCDD), (ii) dibenzofurans (PCDF) and (iii) biphenyls (PCB). There are persistent organic pollutants, and will be present in the environment for many years. Their toxicity is believed to be mediated by the binding to the aromatic hydrocarbon receptor (AhR); however, little is known about the biology of these compounds. For instance, the most potent dioxin-like molecule, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered by the International Agency for Research in Cancer as a human carcinogen, although this has not been confirmed by a 40-year follow up of the population of Seveso who was exposed to TCDD following an explosion of a chemical reactor in the ICMESA factory in July 1976. On the other hand, TCDD and other chlorinated compounds induce a severe cutaneous syndrome, known as chloracne, in which sebaceous glands are replaced by hamartoma. These compounds are toxic for the gut, as well as the liver and the pancreas. The toxicity of these compounds cannot be explained only by their activation of AhR, because various structurally-unrelated compounds found in plants and vegetables may activate AhR without inducing toxicity. These data confirm the need for more fundamental research on these compounds to better understand their mechanism of toxicity.
Dr. Olivier Sorg
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- Polyhalogenated Aromatic Hydrocarbons (PHAH)
- Cell Signaling