Emerging Environmental Pollutants and Their Impact on Human Health

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Emerging Contaminants".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1404

Special Issue Editors


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Guest Editor
Department of Internal Medicine, En Chu Kong Hospital, New Taipei City 237, Taiwan
Interests: internal medicine; epidemiology; endocrine disruptor; nephrology; heavy metals; epigenetics; cardiovascular disease; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wenchang Road, Shilin District, Taipei City 111, Taiwan
Interests: internal medicine; nephrology; metabolic syndrome; genetic diagnosis; molecular medicine
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Nephrology, New Taipei Municipal TuCheng Hospital, New Taipei City, Taiwan
Interests: internal medicine; nephrology; cardiovascular disease; diabetic kidney disease; metabolic syndrome
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Emerging environmental contaminants, such as pharmaceutical residues, endocrine-disrupting chemicals, microplastics, and advanced industrial compounds, present a growing threat to human health. These pollutants, introduced into the environment through industrial activities, urban waste, and agricultural practices, are often persistent, bioaccumulative, and capable of triggering adverse health effects even at low concentrations. Despite increasing awareness, significant gaps remain in our understanding of their toxicological profiles and mechanisms of action.

This Special Issue of Toxics is dedicated to advancing knowledge on the human health impacts of emerging contaminants. We invite original research articles, reviews, and case studies that address critical aspects of this field, including (but not limited to):

  • Toxicokinetics and toxicodynamics of emerging contaminants in humans;
  • Epidemiological studies linking exposure to health outcomes;
  • Development of biomarkers for exposure and effect;
  • Mechanisms of action and their links to chronic diseases;
  • Interaction between multiple contaminants and synergistic health effects;
  • Vulnerable populations (e.g., children, pregnant women, elderly) and differential health impacts;
  • Epigenetic and transgenerational effects of contaminants;
  • Influence of emerging contaminants on microbiome health and its implications for overall well-being;

By situating this issue within the expanding body of environmental health research, we aim to illuminate the pathways by which these pollutants affect human health, highlight knowledge gaps, and promote strategies to mitigate their impact.

Dr. Chien Yu Lin
Dr. Yu-Wei Fang
Dr. Ching-Chung Hsiao
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging contaminants
  • cohort studies
  • epigenetics
  • oxidative stress
  • cardiovascular disease
  • endocrine disruptors
  • monoterpenes
  • glyphosate
  • human health

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Published Papers (2 papers)

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Review

21 pages, 1266 KiB  
Review
Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies
by Maryam Pyambri, Joaquim Jaumot and Carmen Bedia
Toxics 2025, 13(4), 297; https://doi.org/10.3390/toxics13040297 - 11 Apr 2025
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Abstract
Organophosphate flame retardants (OPFRs) have increasingly replaced polybrominated diphenyl ethers (PBDEs) in various consumer products and raw materials, due to regulatory restrictions on PBDEs. However, concerns about the toxicity and environmental persistence of OPFRs are growing. This review summarizes current research on the [...] Read more.
Organophosphate flame retardants (OPFRs) have increasingly replaced polybrominated diphenyl ethers (PBDEs) in various consumer products and raw materials, due to regulatory restrictions on PBDEs. However, concerns about the toxicity and environmental persistence of OPFRs are growing. This review summarizes current research on the toxicity of OPFRs, with a focus on New Approach Methodologies (NAMs) that aim to eliminate the need for animal testing. NAMs, including in vitro models, omics technologies, and computational methods, provide valuable insights into the cellular and molecular effects of OPFR exposure. Evidence suggests that OPFRs may disrupt multiple organ systems, including the nervous, hepatic, pulmonary, reproductive, and endocrine systems. Additionally, the metabolic transformation of OPFRs can increase their toxicity, raising concerns about long-term exposure risks. While NAM studies provide valuable insights, further research is needed to refine risk-assessment frameworks and improve our understanding of the long-term effects of OPFR exposure, particularly at concentrations found in the environment. This new knowledge will help develop more accurate regulatory guidelines and ensure the better protection of public and environmental health. Full article
(This article belongs to the Special Issue Emerging Environmental Pollutants and Their Impact on Human Health)
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14 pages, 311 KiB  
Review
Evaluation of Ecotoxicity in Waste Leachate: A Current Status of Bioassay and Chemical Analysis
by Lia Kim, Jin Il Kwak and Youn-Joo An
Toxics 2025, 13(3), 198; https://doi.org/10.3390/toxics13030198 - 10 Mar 2025
Viewed by 507
Abstract
As global waste generation increases, waste toxicity has become a significant global issue. Among various hazardous properties, ecotoxicity refers to the risks that waste may pose to the environment. It is evaluated through aquatic bioassays to assess the effects of leaching contaminants, as [...] Read more.
As global waste generation increases, waste toxicity has become a significant global issue. Among various hazardous properties, ecotoxicity refers to the risks that waste may pose to the environment. It is evaluated through aquatic bioassays to assess the effects of leaching contaminants, as well as through soil assessments where waste is buried. To clarify these issues, this study collected waste leaching methods from international organizations and various countries and analyzed case studies of bioassays for waste leachates. The criteria for determining the ecotoxicity of waste leachates were also reviewed, revealing inconsistencies in leaching methods across the European Union, the United States, Canada, and Asian countries. Additionally, various bioassays were applied to assess waste leachates, further contributing to inconsistencies. Given these variations, we recommend developing a unified leaching method, standardized bioassays, and consistent criteria for assessing the toxicity of waste leachates. Full article
(This article belongs to the Special Issue Emerging Environmental Pollutants and Their Impact on Human Health)
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