Symmetry or Asymmetry Signal Interaction during Cell Death or Autophagy with Pathogens Infection

Dear Colleagues,

In biological systems, the concept of symmetry is involved in morphology, diversity, molecular evolution, and the origin of life. For this Special Issue, we would like to introduce new concepts in biological symmetry from cellular signaling crosstalk to dissect this interesting issue. For several decades, apoptosis has taken center stage as the principal mechanism of programmed cell death (type I cell death) in mammalian tissues and necroptosis (type III cell death). Autophagic cell death (type II) is characterized by the massive accumulation of autophagic vacuoles in the cytoplasm of cells. The autophagic process is activated as an adaptive response to a variety of extracellular and intracellular stresses, including nutrient deprivation, hormonal or therapeutic treatment, pathogenic infection, aggregated and misfolded proteins, and damaged organelles. Increasing evidence indicates that autophagy is associated with several pathological processes, including viral pathogenesis. The regulation of autophagy in viral expression and replication is complex since it can enhance viral replication in host cells while also acting to suppress the virus expression and evasion. This Special Issue will focus on recent advances in symmetry or non-symmetry signaling crosstalk between autophagy and cell death, which will provide new insights into pathogen control and viral evasion.

Prof. Jiann-Ruey Hong
Dr. Anita Pinar
Guest Editors

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