Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.9
2.7
Journals
Symmetry
Special Issues
Asymmetric Reactions
share announcement

Asymmetric Reactions

A special issue of Symmetry (ISSN 2073-8994). This special issue belongs to the section "Chemistry: Symmetry/Asymmetry".

Deadline for manuscript submissions: closed (29 September 2020) | Viewed by 2576

Special Issue Editor

Prof. Dr. Renato Dalpozzo

E-Mail Website
Guest Editor
Dipartimento di Chimica e Tecnologie Chimiche, Università della Calabria, 87030 Arcavacata di Rende (CS), Italy
Interests: the reactivity of organometallic compounds with aromatic systems; the use of dianions derived from enamino carbonyl compounds; the stereoselective reduction of various classes of ketones; the development of new Lewis acid systems; enantioselective organocatalysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Asymmetric reactions have assumed growing importance among organic reactions since the beginning of this century. Metal chiral complexes as catalysts, chiral pool, easily available chiral organic products, and chiral organocatalysts have been employed to perform these syntheses.

The widespread dissemination of this topic encouraged me to launch a Special Issue to enrich the knowledge of organic chemists, and, thus, new synthetic methods or reviews collecting data on known reactions are welcome.

This Special Issue will be of interest to organic chemists developing new synthetic methods and others interested in their application to the preparation of chiral organic natural products employable in industry, medicine, and biology.

The audience of potential readers is, therefore, very broad and I hope that many of you contribute your research to this Special Issue.

Prof. Dr. Renato Dalpozzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Asymmetric synthesis
  • Chiral metal catalysis
  • Organocatalysis
  • Chiral pool
  • Heterogeneous catalysis
  • Homogeneous catalysis
  • Asymmetric protecting groups.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 5558 KiB  
Article
Design, Construction, and Characterization of a New Regioisomer and Diastereomer Material Based on the Spirooxindole Scaffold Incorporating a Sulphone Function
by Abdullah Mohammed Al-Majid, Saied M. Soliman, Matti Haukka, M. Ali, Mohammad Shahidul Islam, Mohammed Rafi Shaik and Assem Barakat
Symmetry 2020, 12(8), 1337; https://doi.org/10.3390/sym12081337 - 10 Aug 2020
Cited by 14 | Viewed by 2279
Abstract
The 1,3-dipolar cycloaddition reaction is one of the most rapid, and efficient protocols to access, and construct highly divergent heterocycle chiral auxiliaries. Free catalyst synthesis of spirooxindole scaffold incorporating sulphone moiety via one pot–three component reaction of 6-chloro-isatin, L-proline, and the phenylvinylsulphone as [...] Read more.
The 1,3-dipolar cycloaddition reaction is one of the most rapid, and efficient protocols to access, and construct highly divergent heterocycle chiral auxiliaries. Free catalyst synthesis of spirooxindole scaffold incorporating sulphone moiety via one pot–three component reaction of 6-chloro-isatin, L-proline, and the phenylvinylsulphone as dienophile is presented. The new regioisomer and diastereomer was isolated by precipitation without the tedious purification step, and then characterized via NMR and single crystal X-ray diffraction analysis. Using Hirshfeld analysis, the analysis of molecular packing was performed. It depended mainly on strong O…H and N…H interactions, and weak H…H, C…H, and Cl…H interactions as well. DFT calculations were used to optimize the experimental X-ray structure, which was found well matched with the calculated one. Reactivity descriptors based on the energies of the highest occupied (HOMO) and lowest unoccupied (LUMO) molecular orbitals were calculated. Additionally, the donor–acceptor interactions which stabilized the system via σ–σ*, π→π*, n→σ* and n→π* electron delocalization processes were also computed using NBO calculations. The net interaction energies are 49.96, 235.38, 179.66 and 107.06 kJ/mol, respectively. Additionally, the calculated NMR chemical shifts correlated well with the experimental data (R2=0.99). Full article
(This article belongs to the Special Issue Asymmetric Reactions)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop