Special Issue "Amino Acid Chirality"
A special issue of Symmetry (ISSN 2073-8994).
Deadline for manuscript submissions: closed (31 March 2019).
Interests: medicinal chemistry; organic syntheisis; prebiotic chemistry
D-isomers of amino acids are uncommon in living organisms; in fact, they are usually called “non-natural” amino acids. Moreover, D-stereoisomers were long considered to have minor functions in biological processes compared to L-ones. On the other hand, evidence has shown that D-amino acids are present in bacterial cell walls, antibiotics, mammals, and in humans and also that they possess specific biological functions.
D-amino acids, having unique stereochemistry properties, present increased resistance towards most endogenous enzymes, and their metabolisms are associated with neurological disorders, such as schizophrenia, ischemia, epilepsy and neurodegeneration.
This Special Issue intends to cover recent advances in the chemistry and the therapeutic uses of D-amino acids. This includes identification in a prebiotic scenario, the preparation, the incorporation in peptides and peptidomimetics, and their biological evaluations.
Prof. Dr. Lorenzo Botta
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Symmetry is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- D amino acids
- prebiotic chemistry
- biological activity