Amperometric Biosensors

Dear Colleagues,

More than 50 years ago, Clark and Lyons created the first biosensor: a glucose amperometric sensor. They coupled a Clark amperometric sensor for dissolved oxygen with an enzyme, glucose oxidase, which was immobilized on the tip of the electrode with a cellophane membrane. This method of bio-quantitative-assaying was simple, quick, and cheap. In subsequent pioneering years, the assay was extensively and profitably developed for diabetes monitoring.

Since that time, many improvements and applications were developed to not only increase the analytical performance of these amperometric biosensors, but also to prolong the lifetime of several immobilized biological molecules. Developments concerned such molecules’ oriented immobilization, the miniaturization of transducers, and automated, long-term monitoring applications with respect to several fields, which range from medicine, to environmental science and food quality studies.

Currently, improvements in amperometric biosensors mainly concern new materials for disposable electrodes, their deposition techniques (i.e., screen and ink-jet printing) and nanostructures (i.e., nanoelectrode ensembles), engineered sensing biological molecules, their electrochemical addressing and reversible and oriented immobilization, micro-fluidic devices, and Lab-on-a-Chip devices. These improvements reflect the cross interaction of several disciplines and technologies, which range from (without being exhaustive) chemistry, biology, physics, and molecular biology, to nanotechnology, micro-fabrication, and electronic engineering.

This Special Issue aims to bring together articles discussing innovative applications of amperometric biosensors, and to share the benefit of these new ideas and concepts, which are employed in multiple fields, with authors and readers of the journal, who have varying interests.

Both review articles and original research papers relating to the application of amperometric biosensors are solicited.

Dr. Roberto Pilloton
Guest Editor

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