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Bioimpedance Measurements and Microelectrodes: Second Edition

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 550

Special Issue Editors


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Guest Editor
Instituto de Microelectronica de Sevilla (US/IMSE), Universidad de Sevilla, Sevilla, Spain
Interests: biomedical circuits and systems; bio-sensors; laboratory on-a-chip (LoC); bioimpedance; microelectrode; design for test
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Instituto de Microelectronica de Sevilla (US/IMSE), Universidad de Sevilla, 41004 Sevilla, Spain
Interests: bioimpedance; biomedical circuits and systems; analog integrated circuit design; wearable devices; biosensors; stem cells electro-stimulation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Department of Electronic Technology, IMSE-CNM-CSIC, University of Seville, 41012 Seville, Spain
Interests: wearable sensors; textile electrodes; physiological monitoring; wearable electronics

Special Issue Information

Dear Colleagues,

Bioimpedance measurements are an essential technique in the field of biomedicine. They are used to analyze the electrical properties of biological tissues, cells, and other biological samples. By applying an electrical current/voltage and measuring the resulting voltage/current, bioimpedance can provide valuable information about tissue composition, cellular health, and physiological processes. This Special Issue delves into the latest advancements and applications of bioimpedance measurements, with particular emphasis on the role of microelectrodes.

Microelectrodes have become pivotal in enhancing the precision and effectiveness of bioimpedance measurements. Due to their small size, they allow for high-resolution recordings and can access regions that are difficult to measure with traditional electrodes. This makes them ideal for minimally invasive procedures, providing detailed data while reducing patient discomfort and risk.

The articles in this Special Issue should explore various facets of bioimpedance and microelectrode technology. Topics of interest include innovations in microelectrode design, improvements in bioimpedance measurement techniques, and the integration of these technologies into clinical and research settings. Applications range from cardiac monitoring and neural activity recording to cancer detection, cellular analysis, and tissue engineering.

By bringing together cutting-edge research and practical applications, this Special Issue aims to highlight the transformative potential of bioimpedance measurements and microelectrode technology in modern medicine.

The topic of bioimpedance measurements and microelectrode technology aligns perfectly with the scope of Sensors for several reasons:

Innovative sensor technology: Bioimpedance measurement systems and microelectrodes are at the forefront of sensor innovation. Microelectrodes, as highly sensitive and miniaturized sensors, provide critical advancements in the ability to measure the electrical properties of biological entities with high precision and resolution.

Biomedical applications: The application of bioimpedance sensors in medical diagnostics and research exemplifies the use of sensor technology to address complex biomedical challenges. This includes applications such as cardiac monitoring, neural activity recording, cancer detection, and tissue engineering, which are all of interest to the readership of Sensors.

Integration and systems development: The integration of bioimpedance sensors and microelectrodes into complex systems for real-time monitoring and diagnostics represents significant progress in sensor system development. This includes the design, optimization, and deployment of sensor networks and systems in healthcare settings.

Technological advancements: Advances in microelectrode design, materials, and fabrication techniques are pivotal for the development of next-generation sensors. These technological advancements contribute to the broader field of sensor technology, aligning with the journal's emphasis on cutting-edge research and innovation.

Multidisciplinary approach: Bioimpedance and microelectrode research is inherently multidisciplinary, encompassing fields such as biomedical engineering, materials science, electrical engineering, and physiology. This multidisciplinary nature is a key aspect of Sensors, which encourages contributions that span different scientific and engineering disciplines.

Impact on sensor development: Research on bioimpedance and microelectrodes impacts the development of sensors for various applications beyond biomedicine, including environmental monitoring, food safety, and industrial applications. This broad impact is relevant to the diverse topics covered by Sensors.

By focusing on these aspects, the topic of bioimpedance measurements and microelectrode technology fits seamlessly within the scope of Sensors, contributing to the advancement of sensor technology and its application in a wide range of fields.

Prof. Dr. Gloria Huertas
Dr. Alberto Yufera
Guest Editors

Dr. Santiago Fernández Scagliusi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioimpedance
  • microelectrodes
  • biomedical diagnostics
  • electrical properties of biological samples
  • cellular health
  • high-resolution measurements
  • minimally invasive techniques
  • microelectrode design
  • bioimpedance systems
  • tissue characterization
  • cellular analysis
  • clinical applications
  • electrophysiology
  • tissue engineering
  • cancer detection
  • neural recording
  • physiological processes

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Published Papers (1 paper)

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Review

25 pages, 1253 KB  
Review
Bioimpedance-Based Measurements of In Vitro Biological Cell Barrier Integrity: A Review and Framework for the Acquisition and Analysis Strategies
by Shaginth Sivakumar, João Pinheiro Marques and Adrien Roux
Sensors 2026, 26(8), 2477; https://doi.org/10.3390/s26082477 - 17 Apr 2026
Viewed by 382
Abstract
In vitro cell barrier models have been increasingly integrated into pharmaceutical and academic research pipelines to evaluate drug safety and drug delivery due to a shift towards New Approach Methodologies (NAMs) in research and regulatory safety assessment. Such models require reliable and interpretable [...] Read more.
In vitro cell barrier models have been increasingly integrated into pharmaceutical and academic research pipelines to evaluate drug safety and drug delivery due to a shift towards New Approach Methodologies (NAMs) in research and regulatory safety assessment. Such models require reliable and interpretable functional readouts. Bioimpedance-based monitoring, particularly transepithelial/endothelial electrical resistance (TEER), is a widely adopted readout due to its non-invasive and real-time capabilities. However, substantial variability arises from differences in measurement settings, frequency selection, electrode configuration, impedance measuring techniques, and data analysis strategies. In numerous studies, TEER is approximated from single-frequency impedance magnitude measurements, which do not isolate the resistive component associated with tight junction-mediated paracellular transport but instead reflect the combined response of a coupled electrochemical system. This review clarifies impedance measuring techniques and systematically analyzes impedance-based measurement and analysis strategies for in vitro biological cell barrier integrity. We compare mono-frequency and broadband acquisition approaches, examine the influence of electrode–electrolyte interfaces, electrode geometry, and culture configuration, and evaluate equivalent circuit modeling and phase-resolved electrical impedance spectroscopy (EIS). Based on this comparison, we propose a three-level analytical hierarchy adapted to experimental objectives and instrumentation constraints. We conclude that phase-informed impedance analysis and harmonized reporting are essential to improve measurement reproducibility, inter-platform comparability, and integration of impedance-derived cell barrier assessment within NAMs-oriented research workflows. Full article
(This article belongs to the Special Issue Bioimpedance Measurements and Microelectrodes: Second Edition)
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