Special Issue "Particulate Processes in the Formulation of Pharmaceuticals, Nutraceuticals and Bioactive Compounds"
Deadline for manuscript submissions: closed (31 December 2021).
Interests: drug formulation; characterization of dosage forms; formulation of natural products with therapeutic perspectives
Special Issues, Collections and Topics in MDPI journals
Interests: development and evaluation of pharmaceutical formulations and excipients; particle engineering and characterization
Particulate processes producing particles in size scales from nanometers to millimeters play a major role in health sciences and the product market. This is because about 60% of marketed pharmaceuticals are solid dosage forms and about the same percentage of the overall nutraceutical consumption is accounted by dry excipients. The large number of orally administered poorly water-soluble drugs has necessitated the development of modern particle engineering processes aiming for improvement of solubility, permeability, and targeting effectiveness. Nanomilling, high-pressure homogenization, self-emulsification, and solid-lipid technology give particles in the nanosize range; spray-drying, freeze drying, and freeze spraying into liquid give composite microparticles in the micrometers range; electrospinning, electrospraying, and hot melt extrusion are able to produce drugs in the form of pharmaceutical salts, cocrystals, amorphous and co-amorphous drug systems, which after mechanical milling give particles in an intermediate size range of 10–100 μm. Finally, wet and dry granulation, melt granulation, and extrusion/spheronization are widely applied to give a free-flowing powder product split into multiple-unit dosage forms where the dose is subdivided into units of millimeter size particles with therapeutic and technological benefits. Similar considerations as set above apply to nutraceuticals with therapeutic properties, such as essential oils, prebiotics, and probiotics and other microorganisms, e.g., vaccines.
This Special Issue welcomes contributions of original research work and reviews reporting established and emerging technologies of particle engineering, the application of which leads to improvements in the properties of the particulate products, namely in the solubility, redispersibility, release, and permeability of the bioactive compound, handling (packing ability and flowability), compressibility and compactibility, swelling, matrix forming ability, and suitability for thermal processing. Application of mathematical models to describe the mechanisms and kinetics of particle formation, critical process factors involved in product quality and production yield, novel methods of particle structure, and solid-state characterization are encouraged.
Assoc. Prof. Dr. Ioannis Nikolakakis
Assoc. Prof. Dr. Nizar Al-Zoubi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- particle technology
- controlled drug delivery
- protein drugs
- cospray drying