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Taste Masking of Nizatidine Using Ion-Exchange Resins

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand
Author to whom correspondence should be addressed.
Processes 2019, 7(11), 779;
Received: 23 September 2019 / Revised: 22 October 2019 / Accepted: 28 October 2019 / Published: 30 October 2019
The purpose of this study was to mask the bitter taste of nizatidine (NZD) using cation-exchange resins. Amberlite IRP-69 and Dowex-50 containing cross-linked polystyrene backbones were used. The drug resin complexes were prepared by batch process using drug: resin ratios of 1:1, 1:3, and 1:5. The optimum drug: resin ratio and the time required for maximum percentage drug loading into the complexes were determined. The selected drug-resin complexes were evaluated for morphology, drug release, and taste. The NZD-Dowex complex was obtained at a drug: resin ratio of 1:5 using a stirring time of 1 h in order to get 100% loading of NZD. The NZD-Dowex complex had a spherical shape and smooth texture similar to Dowex resin. The NZD-Dowex complex with a ratio of 1:5 showed that in vitro drug release of 4.27% at 5 min in simulated salivary fluid of pH 6.8 and 99.67% at 1 h in simulated gastric fluid of pH 1.2. NZD’s bitter taste was effectively masked when it formed a complex with Dowex at a ratio of 1:5. This was proved by an electronic tongue and human test panel. View Full-Text
Keywords: nizatidine; ion-exchange resins; Dowex; Amberlite; electronic tongue nizatidine; ion-exchange resins; Dowex; Amberlite; electronic tongue
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MDPI and ACS Style

Panraksa, P.; Boonsermsukcharoen, K.; Hwang, K.-M.; Park, E.-S.; Jantrawut, P. Taste Masking of Nizatidine Using Ion-Exchange Resins. Processes 2019, 7, 779.

AMA Style

Panraksa P, Boonsermsukcharoen K, Hwang K-M, Park E-S, Jantrawut P. Taste Masking of Nizatidine Using Ion-Exchange Resins. Processes. 2019; 7(11):779.

Chicago/Turabian Style

Panraksa, Pattaraporn, Kasidech Boonsermsukcharoen, Kyu-Mok Hwang, Eun-Seok Park, and Pensak Jantrawut. 2019. "Taste Masking of Nizatidine Using Ion-Exchange Resins" Processes 7, no. 11: 779.

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