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Article

Taste Masking of Nizatidine Using Ion-Exchange Resins

1
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
2
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
3
Cluster of Research and Development of Pharmaceutical and Natural Products Innovation for Human or Animal, Chiang Mai University, Chiang Mai 50200, Thailand
*
Author to whom correspondence should be addressed.
Processes 2019, 7(11), 779; https://doi.org/10.3390/pr7110779
Received: 23 September 2019 / Revised: 22 October 2019 / Accepted: 28 October 2019 / Published: 30 October 2019
The purpose of this study was to mask the bitter taste of nizatidine (NZD) using cation-exchange resins. Amberlite IRP-69 and Dowex-50 containing cross-linked polystyrene backbones were used. The drug resin complexes were prepared by batch process using drug: resin ratios of 1:1, 1:3, and 1:5. The optimum drug: resin ratio and the time required for maximum percentage drug loading into the complexes were determined. The selected drug-resin complexes were evaluated for morphology, drug release, and taste. The NZD-Dowex complex was obtained at a drug: resin ratio of 1:5 using a stirring time of 1 h in order to get 100% loading of NZD. The NZD-Dowex complex had a spherical shape and smooth texture similar to Dowex resin. The NZD-Dowex complex with a ratio of 1:5 showed that in vitro drug release of 4.27% at 5 min in simulated salivary fluid of pH 6.8 and 99.67% at 1 h in simulated gastric fluid of pH 1.2. NZD’s bitter taste was effectively masked when it formed a complex with Dowex at a ratio of 1:5. This was proved by an electronic tongue and human test panel. View Full-Text
Keywords: nizatidine; ion-exchange resins; Dowex; Amberlite; electronic tongue nizatidine; ion-exchange resins; Dowex; Amberlite; electronic tongue
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MDPI and ACS Style

Panraksa, P.; Boonsermsukcharoen, K.; Hwang, K.-M.; Park, E.-S.; Jantrawut, P. Taste Masking of Nizatidine Using Ion-Exchange Resins. Processes 2019, 7, 779. https://doi.org/10.3390/pr7110779

AMA Style

Panraksa P, Boonsermsukcharoen K, Hwang K-M, Park E-S, Jantrawut P. Taste Masking of Nizatidine Using Ion-Exchange Resins. Processes. 2019; 7(11):779. https://doi.org/10.3390/pr7110779

Chicago/Turabian Style

Panraksa, Pattaraporn, Kasidech Boonsermsukcharoen, Kyu-Mok Hwang, Eun-Seok Park, and Pensak Jantrawut. 2019. "Taste Masking of Nizatidine Using Ion-Exchange Resins" Processes 7, no. 11: 779. https://doi.org/10.3390/pr7110779

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