Special Issue "Biofabrication Scaffold in Regenerative Medicine"

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Materials Processes".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editors

Dr. Ming-You Shie

Guest Editor
School of Dentistry, China Medical University, Taichung City 40447, Taiwan
Interests: tissue engineering; biofabrication; 3D bioprinting; bioceramics; bioinspired materials; bio-inks; medical devices
Dr. Kan Wang

Co-Guest Editor
The Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA
Interests: additive manufacturing; printed electronics; nanomanufacturing; biomanufacturing; biomedical devices

Special Issue Information

Dear Colleagues,

The emergence of biofabrication technology and its related novel concepts such as 3D and 4D bioprinting has allowed us to fabricate and mimic complex native tissues. Numerous studies have since been reported attempting to recreate native tissues by searching for the best printing parameters and conditions. The parameters vary vastly from the suitability of the biomaterials, scaffold geometry, physical and biological stimulations, and the application of biochemical and biological cues, to searching for the optimal printing conditions. The goal of such tissue engineering is to fabricate complex tissue-like structures for tissue regeneration and personalized treatments such as drug screening and toxicological studies. Of the many parameters involved in bioprinting, the biomaterial plays a huge role in determining the feasibility of constructs for tissue engineering. Biomaterial biocompatibility allows for high cell viability and high retention of growth factors whilst the structural stability and geometry of the printed constructs allows specific cellular proliferation and differentiation. Many studies have attempted to explore suitable biomaterials for various applications by modifying and tuning the characteristics of various biomaterials. Therefore, this Issue is mainly focused on the various novel modifications of biomaterials used for tissue engineering and it is hoped that such a collection of articles could be used as a platform for future brainstorming. 

Dr. Ming-You Shie
Dr. Kan Wang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Please note that for papers submitted after 30 June 2020 an APC of 1500 CHF applies. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • biofabrication
  • bioprinting
  • tissue engineering
  • bioceramic
  • hydrogel
  • 3D scaffold
  • 4D printing
  • biomedical device
  • biostimulation

Published Papers (1 paper)

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Open AccessArticle
The Calcium Channel Affect Osteogenic Differentiation of Mesenchymal Stem Cells on Strontium-Substituted Calcium Silicate/Poly-ε-Caprolactone Scaffold
Processes 2020, 8(2), 198; https://doi.org/10.3390/pr8020198 - 06 Feb 2020
Cited by 1
There had been a paradigm shift in tissue engineering studies over the past decades. Of which, part of the hype in such studies was based on exploring for novel biomaterials to enhance regeneration. Strontium ions have been reported by others to have a [...] Read more.
There had been a paradigm shift in tissue engineering studies over the past decades. Of which, part of the hype in such studies was based on exploring for novel biomaterials to enhance regeneration. Strontium ions have been reported by others to have a unique effect on osteogenesis. Both in vitro and in vivo studies had demonstrated that strontium ions were able to promote osteoblast growth, and yet at the same time, inhibit the formation of osteoclasts. Strontium is thus considered an important biomaterial in the field of bone tissue engineering. In this study, we developed a Strontium-calcium silicate scaffold using 3D printing technology and evaluated for its cellular proliferation capabilities by assessing for protein quantification and mineralization of Wharton’s Jelly mesenchymal stem cells. In addition, verapamil (an L-type of calcium channel blocker, CCB) was used to determine the mechanism of action of strontium ions. The results found that the relative cell proliferation rate on the scaffold was increased between 20% to 60% within 7 days of culture, while the CCB group only had up to approximately 10% proliferation as compared with the control specimen. Besides, the CCB group had downregulation and down expressions of all downstream cell signaling proteins (ERK and P38) and osteogenic-related protein (Col I, OPN, and OC). Furthermore, CCB was found to have 3–4 times lesser calcium deposition and quantification after 7 and 14 days of culture. These results effectively show that the 3D printed strontium-contained scaffold could effectively stimulate stem cells to undergo bone differentiation via activation of L-type calcium channels. Such results showed that strontium-calcium silicate scaffolds have high development potential for bone tissue engineering. Full article
(This article belongs to the Special Issue Biofabrication Scaffold in Regenerative Medicine)
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