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Polymers
Special Issues
Biomedical Composite Materials for Stem Cell Culture
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Biomedical Composite Materials for Stem Cell Culture

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 2354

Special Issue Editors

Dr. Huai-En Lu

E-Mail Website
Guest Editor
Bioresource Collection and Research Center,Food Industry Research and Development Institute, Hsinchu, Taiwan
Interests: iPSC, GelMA, tissue engineering, stem cell, differetiation, cell culture
Dr. Ming-You Shie

E-Mail Website
Guest Editor
School of Dentistry, China Medical University, Taichung City 40447, Taiwan
Interests: tissue engineering; biofabrication; 3D bioprinting; bioceramics; bioinspired materials; bio-inks; medical devices
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomedical composite materials have recently attracted much attention in the field of tissue engineering. The combination of organic or inorganic materials with natural or synthetic materials are especially popular strategies due to their capability to overcome each other’s shortcomings. The combination of materials not only improves manufacture processing, it also enhances physicochemical properties of biomedical composite materials in terms of mechanical properties, bioactivity and degradability. Therefore, there are many novel and new studies focusing on the development of biomedical composite materials for drugs and gene delivery, bioprinting, cell therapy as well as stem cell culture.

Stem cells are an extremely important cell type in the field of tissue engineering, and stem cell culture can be divided into two directions: one is to maintain the undifferentiated state of stem cells, and the other is the guidance and regulation of stem cell differentiation. Studying the effects of biomedical composite materials for stem cells will improve the development of tissue engineering.

The purpose of this Special Issue is to publish cutting-edge applications related to advanced Biomedical composite materials for stem cell culture. All kinds of composite materials either synthetic/natural polymers or newly developed ones and stem cell types such as induced pluripotent stem cells(iPSC), mesenchymal stem cells(MSC) and adult stem cells, are all welcome.

It is a great pleasure to invite you to submit a manuscript for this Special Issue of Polymers.

Dr. Huai-En Lu
Dr. Ming-You Shie
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomolecule
  • biomaterial
  • biopolymer
  • 3D printing
  • Bio-ink
  • multifunctional biomaterials
  • scaffolds
  • biofabrication
  • induced pluripotent stem cell
  • mesenchymal stem cells
  • adult stem cells

Published Papers (1 paper)

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Research

13 pages, 1634 KiB  
Article
Hypothermic Storage of 3D Cultured Multipotent Mesenchymal Stromal Cells for Regenerative Medicine Applications
by Irena Vackova, Eliska Vavrinova, Jana Musilkova, Vojtech Havlas and Yuriy Petrenko
Polymers 2022, 14(13), 2553; https://doi.org/10.3390/polym14132553 - 23 Jun 2022
Cited by 2 | Viewed by 1501
Abstract
The regulatory requirements in cell processing, in the choice of a biomaterial scaffold and in quality control analysis, have to be followed in the clinical application of tissue-engineered grafts. Confirmation of sterility during quality control studies requires prolonged storage of the cell-based construct. [...] Read more.
The regulatory requirements in cell processing, in the choice of a biomaterial scaffold and in quality control analysis, have to be followed in the clinical application of tissue-engineered grafts. Confirmation of sterility during quality control studies requires prolonged storage of the cell-based construct. After storage, preservation of the functional properties of the cells is an important prerequisite if the cells are to be used for cell-based tissue therapies. The study presented here shows the generation of 3D constructs based on Wharton’s jelly multipotent mesenchymal stromal cells (WJ-MSCs) and the clinically-acceptable HyaloFast® scaffold, and the effect of two- and six-day hypothermic storage of 3D cell-based constructs on the functional properties of populated cells. To study the viability, growth, gene expression, and paracrine secretion of WJ-MSCs within the scaffolds before and after storage, xeno-free culture conditions, metabolic, qPCR, and multiplex assays were applied. The WJ-MSCs adhered and proliferated within the 3D HyaloFast®. Our results show different viability of the cells after the 3D constructs have been stored under mild (25 °C) or strong (4 °C) hypothermia. At 4 °C, the significant decrease of metabolic activity of WJ-MSCs was detected after 2 days of storage, with almost complete cell loss after 6 days. In mild hypothermia (25 °C) the decrease in metabolic activity was less remarkable, confirming the suitability of these conditions for cell preservation in 3D environment. The significant changes were detected in gene expression and in the paracrine secretion profile after 2 and 6 days of storage at 25 °C. The results presented in this study are important for the rapid transfer of tissue engineering approaches into clinical applications. Full article
(This article belongs to the Special Issue Biomedical Composite Materials for Stem Cell Culture)
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