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Processes
Special Issues
Research of Bioactive Synthetic and Natural Products Chemistry
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Research of Bioactive Synthetic and Natural Products Chemistry

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Pharmaceutical Processes".

Deadline for manuscript submissions: closed (30 April 2025) | Viewed by 2894

Special Issue Editors

Prof. Dr. Athanasia Varvaresou

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Guest Editor
Laboratory of Chemistry-Biochemistry-Cosmetic Science, Department of Biomedical Sciences, University of West Attica, Panepistimiopolis 1, Ag. Spyridonos 28, Egaleo, 12243 Athens, Greece
Interests: synthesis of bioactive compounds; natural products for skin care; development of skin care products; skin antioxidants; efficacy of cosmetic formulations; skin care for oncology patients; quality control of skin care products; novel quantification assays of bioactive ingredients and their efficacy; skin pharmaceuticals; dermal delivery
Special Issues, Collections and Topics in MDPI journals
Dr. Spyros Papageorgiou

E-Mail Website
Guest Editor
Laboratory of Chemistry-Biochemistry-Cosmetic Science, Department of Biomedical Sciences, University of West Attica, Panepistimiopolis 1, Ag. Spyridonos 28, Egaleo, 12243 Athens, Greece
Interests: development of skin care products; skin antioxidants; quality control of cosmetics; effficacy of cosmetic formulations; Good Manufacturing Practice (GMP) in cosmetics; efficacy of cosmetic formulations; legislation of cosmetic products and medical device products
Special Issues, Collections and Topics in MDPI journals
Dr. Panagoula Pavlou

E-Mail Website
Guest Editor
Laboratory of Chemistry-Biochemistry-Cosmetic Science, Department of Biomedical Sciences, University of West Attica, Panepistimiopolis 1, Ag. Spyridonos 28, 12243 Egaleo, Athens, Greece
Interests: development of skin care products; skin antioxidants; effficacy of cosmetic formulations; in vivo efficacy of cosmetic formulations; formulation; skin pharmaceuticals; sun protection factor and UVA protection; stability studies of skin topical formulations; dermal delivery

Special Issue Information

Dear Colleagues,

Research in novel bioactive ingredients and formulations is constantly expanding. Synthetic and natural products with specialized mechanism of action have aroused the interest of Industry and Academic research. Chemical modifications of compounds of natural origin to improve physicochemical and biological properties is a challenge for experts in biomedical sciences.

The special issue “Research of Bioactive Synthetic And Natural Products Chemistry'” will curate fundamental and applied methods for the development, analysis and biological properties of synthetic and natural products, and final formulations, as well.

Topics include, but are not limited to, methods and/or applications in the following fields:

  • Synthesis and structure elucidation of new synthetic bioactive compounds
  • Isolation, chemistry and biological activity of natural products 
  • Development and effectiveness of innovative bioactive formulations 
  • Quantification of bioactive ingredients

Prof. Dr. Athanasia Varvaresou
Dr. Spyros Papageorgiou
Dr. Panagoula Pavlou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • synthetic chemistry of bioactive compounds
  • chemistry and Isolation of natural products
  • innovative bioactive formulations
  • quantification assays

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

20 pages, 4235 KiB  
Article
Comparative Evaluation of Wound Healing Efficacy of Bombyx mori L. Body Extracts, Gland Extracts, and Cocoon for the Treatment of Second-Degree Burns: A Pilot Study
by Alexandra Kyriaki, Margarita Vidali, Andreas Vitsos, Paschalis Harizanis, Ioannis Sfiniadakis, Christina Barda, Eleftheria Simirioti, Asimina Terezaki and Michail Christou Rallis
Processes 2024, 12(11), 2594; https://doi.org/10.3390/pr12112594 - 18 Nov 2024
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Abstract
Background: The silkworm (Bombyx mori L.) and its cocoon are rich in bioactive proteins like sericin and fibroin, as well as enzymes such as serrapeptase, which possess anti-inflammatory and skin-healing properties. This study aimed to evaluate the in vivo effects of various [...] Read more.
Background: The silkworm (Bombyx mori L.) and its cocoon are rich in bioactive proteins like sericin and fibroin, as well as enzymes such as serrapeptase, which possess anti-inflammatory and skin-healing properties. This study aimed to evaluate the in vivo effects of various silkworm products, including cocoon patches and extracts from the silkworm body and glands, on the healing of second-degree burns. Methods: Hairless, female SKH-2 mice were used to model second-degree burns. The study tested formulations containing 1%, 10%, or 20% silkworm body or gland extracts, as well as cocoon-derived patches. In addition to histopathological and clinical assessments, the study measured parameters including burn size, hydration, transepidermal water loss and thickness. Results: The results of this study demonstrated that, in terms of primary outcomes (complete healing), both the silkworm cocoon and the 20% body extract significantly promoted wound healing, with similar efficacy. All body extracts showed statistical significance in wound area reduction, while the gland extracts had no significant effect. Histopathological evaluation confirmed the superior healing potential of the body extracts increasing by increased concentration and cocoon. This novel insight into the therapeutic properties of silkworm body extracts opens new opportunities for the development of cost-effective, renewable second-degree burn healing treatments. Full article
(This article belongs to the Special Issue Research of Bioactive Synthetic and Natural Products Chemistry)
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15 pages, 1805 KiB  
Article
Advanced HPLC Method with Diode Array Detection Using a Phenyl-Bonded Column for Simultaneous Quantitation of Three Sunscreen Filters in a Moisturizing Sunscreen Cream for Acne-Prone Skin
by Panayiotis Feidias, Irene Panderi, Georgia Eleni Tsotsou, Ioanna Balatsouka, Spyridon Papageorgiou and Athanasia Varvaresou
Processes 2024, 12(11), 2309; https://doi.org/10.3390/pr12112309 - 22 Oct 2024
Viewed by 1409
Abstract
This study introduces a novel, robust, and efficient method for the simultaneous quantitative determination of three sunscreen filters, namely, 4-methylbenzylidene camphor, octyl methoxycinnamate, and avobenzone, in a moisturizing sunscreen cream specifically designed for acne-prone skin. The method employs high-performance liquid chromatography with photodiode-array [...] Read more.
This study introduces a novel, robust, and efficient method for the simultaneous quantitative determination of three sunscreen filters, namely, 4-methylbenzylidene camphor, octyl methoxycinnamate, and avobenzone, in a moisturizing sunscreen cream specifically designed for acne-prone skin. The method employs high-performance liquid chromatography with photodiode-array detection, providing a reliable separation of the analytes. Chromatographic separation was achieved using a Fortis Phenyl analytical column (150.0 × 2.1 mm, 5 μm), with isocratic elution at a flow rate of 0.4 mL/min. The mobile phase was composed of a 57/43 (v/v) mixture of acetonitrile/45 mM aqueous ammonium formate solution, ensuring sufficient resolution and peak symmetry for the target compounds. The method was validated comprehensively for critical performance parameters, including linearity, precision, accuracy, and robustness. Linearity was established across a suitable range for all three analytes, with high correlation coefficients. Precision was confirmed with intra-run and total precision coefficients of variation of ≤4.6%, while accuracy assessments yielded a percent recovery between 98.6 and 100.4, for all quality control levels. Additionally, the method was able to effectively separate the sunscreen filters from other cosmetic ingredients, such as [β-(1.3), (1.6)-D-glucan], low molecular weight (LMW) hyaluronic acid and plant extracts ensuring specificity in complex formulations. This straightforward and time efficient sample preparation process, involving methanol extraction followed by serial dilution, makes the method suitable for routine quality control in cosmetic laboratories. The method was successfully applied to the analysis of two different lots of a commercial sunscreen cream, achieving excellent recovery for all filters, ranging between 94.6% and 99.8%, thus demonstrating its reliability and applicability for the quality control of cosmetics. Full article
(This article belongs to the Special Issue Research of Bioactive Synthetic and Natural Products Chemistry)
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