Process Design and Functional Mechanisms of Nanostructured Drug Delivery Systems
A Special Issue of Processes (ISSN 2227-9717) belonging to the section "Pharmaceutical Processes".
Deadline for manuscript submissions: 31 October 2026 | Viewed by 243
Editors
Interests: nanostructured drug delivery systems; controlled release systems; process modeling; AI-driven chemical engineering modeling
Interests: drug formulation; characterization of dosage forms; formulation of natural products with therapeutic perspectives
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanostructured drug delivery systems have emerged as powerful platforms for precision therapeutics due to their tunable physicochemical properties, high surface-area-to-volume ratio and capacity for controlled and targeted release. Liposomes, polymeric nanoparticles, micelles, dendrimers and hybrid nanocarriers enable enhanced bioavailability, reduced systemic toxicity and improved therapeutic efficacy.
Despite significant advances in nanomaterial development, the translation of nanoscale drug carriers from laboratory synthesis to clinically relevant and industrially scalable systems remains a major engineering challenge. Critical issues include mass transfer limitations, release kinetics, transport phenomena in complex biological environments, scale-up strategies, process reproducibility, continuous manufacturing and quality-by-design considerations.
This Special Issue aims to provide a focused engineering perspective on nanostructured drug delivery systems, emphasizing mechanistic modeling, process design, system optimization and scalable manufacturing approaches. Contributions that integrate materials development with process systems engineering principles are particularly encouraged.
Suggested topics include, but are not limited to, the following:
- Transport phenomena in nanostructured drug carriers
- Modeling and simulation of drug-release kinetics
- Process design and scale-up of nanoparticle production
- Microfluidic and continuous manufacturing of liposomes and nanoparticles
- Quality-by-design and process control strategies
- Stability and storage modeling of nanosystems
- Mechanistic modeling of nanocarrier–cell interactions
- Techno-economic analysis of nanosystem manufacturing
- Regulatory-oriented process validation approaches
Dr. Waad Abuwatfa
Prof. Dr. Ioannis Nikolakakis
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nanostructured materials
- drug delivery systems
- liposomes
- targeted therapy
- modeling and simulation
- controlled release
- nanomaterial scale-up
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