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Journals
Processes
Special Issues
New Advances in Green Extraction Technology for Natural Products
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New Advances in Green Extraction Technology for Natural Products

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Separation Processes".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1896

Special Issue Editors

Dr. Marijana Popović

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Guest Editor
Department of Applied Science, Institute for Adriatic Crops and Karst Reclamation, Split, 21000, Croatia
Interests: plant secondary metabolites; bioactive compounds; medicinal and aromatic plants; essential oils; green extraction; chromatography; mass spectrometry; biological activities
Dr. Maja Veršić Bratinčević

E-Mail Website
Guest Editor
Department of Applied Science, Institute for Adriatic Crops and Karst Reclamation, 21000 Split, Croatia
Interests: bioactive compounds; plant metabolites; extraction optimization; phenolics; antioxidation; chromatography; mass spectrometry
Dr. Ivana Generalić Mekinić

E-Mail Website
Guest Editor
Department of Food Technology and Biotechnology, Faculty of Chemistry and Technology, University of Split, 21000 Split, Croatia
Interests: food chemistry; herbs; natural extracts; antioxidants; antimicrobials; phytochemicals; phenolic compounds
Special Issues, Collections and Topics in MDPI journals
Dr. Danijela Skroza

E-Mail Website
Guest Editor
Department of Food Technology and Biotechnology, Faculty of Chemistry and Technology, University of Split, 21000 Split, Croatia
Interests: food microbiology; green extraction technologies; chemical characterisation; in vitro antioxidant; antimicrobial activity; application of bioactive compunds in foods
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Green and sustainable extraction techniques are being intensively developed nowadays to replace or reduce the conventional, environmentally unfriendly, solvent-based techniques. The development of these novel techniques, such as microwave-assisted extraction, ultrasound-assisted extraction, pressure-assisted liquid extraction, supercritical CO2 extraction, pulsed electric field assisted extraction, and enzyme-assisted extraction, etc., helps to minimise the negative impact on the environment and human health by reducing or eliminating the use of extraction solvent, as well as by reducing extraction time and energy consumption. Some of the major industries, such as the food, pharmaceutical, cosmetic and agricultural industries, are increasingly using extracts from natural products and/or their specific metabolites. At least 50% of the energy consumption in industrial processes is related to the extraction cycle, meaning that the implementation of new and optimization of existing extraction methods are important economic and environmental factors.

In most cases, the application of green extraction techniques leads to an increase in the extraction yield of the target metabolites, as well as differences in the chemical composition of the isolated natural products.

This Special Issue on “New Advances in Green Extraction Technology of Natural Products” will present new research advances in green extraction technologies that lead to improved extraction reproducibility, higher extraction yields, reduced energy, and solvent consumption.

We hope you will consider participating in this Special Issue.

Sincerely,

Dr. Marijana Popović
Dr. Maja Veršić Bratinčević
Prof. Dr. Ivana Generalić Mekinić
Dr. Danijela Skroza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • secondary metabolites
  • phytochemicals
  • isolation
  • green extraction
  • ultrasound-assisted extraction
  • microwave-assisted extraction
  • supercritical fluid extraction
  • identification and quantification of secondary metabolites

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 626 KiB  
Article
Optimization and Kinetic Modelling of Hydroxycinnamic Acid Extraction from Anethum graveolens Leaves
by Violeta Jevtovic, Khulood Fahad Saud Alabbosh, Reem Ali Alyami, Maha Awjan Alreshidi, Maha Raghyan Alshammari, Badriah Alshammari, Jelena Mitić and Milan Mitić
Processes 2025, 13(5), 1297; https://doi.org/10.3390/pr13051297 - 24 Apr 2025
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Abstract
This study focused on optimizing key extraction parameters (ethanol concentration, temperature, and time) to enhance the extraction of hydroxycinnamic acids from A. graveolens leaves, applying a replicated 23 full factorial design. The experimental results demonstrated that extraction conditions significantly influenced the yield [...] Read more.
This study focused on optimizing key extraction parameters (ethanol concentration, temperature, and time) to enhance the extraction of hydroxycinnamic acids from A. graveolens leaves, applying a replicated 23 full factorial design. The experimental results demonstrated that extraction conditions significantly influenced the yield of hydroxycinnamic acids. The optimum conditions were 50% ethanol for 80 min at 50 °C, yielding 103.75 µg/g of chlorogenic acid (ChA), 6.05 µg/g of ferulic acid (FA), and 2.19 µg/g of sinapic acid (SA). Therefore, the extract obtained with 50% ethanol showed the highest levels of polyphenols, flavonoids, and antioxidant potential, highlighting its suitability for use in both food-related products and pharmaceutical formulations. Additionally, the applicability of different mathematical models (unsteady-state diffusion, parabolic diffusion, and power law models, as well as Ponomaryov’s and Elovich’s equations) to describe and better understand the kinetics of hydroxycinnamic acid extraction from dill leaves was evaluated. The fit of each kinetic model to the experimental data was assessed using the root mean square error and the coefficient of determination. Among the five kinetic models, the unsteady-state diffusion model and Ponomaryov’s equation provided the best fit, exhibiting the highest accuracy. The activation energy for the extraction process was determined to be 5.85, 6.46, and 7.59 kJ/mol for ChA, FA, and SA, respectively. The extraction of hydroxycinnamic acids from dill leaves was found to be endothermic, irreversible, and spontaneous. Full article
(This article belongs to the Special Issue New Advances in Green Extraction Technology for Natural Products)
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16 pages, 3232 KiB  
Article
Maximizing the Hesperidin Extraction Using Supercritical Carbon Dioxide and Ethanol: Theoretical Prediction and Experimental Results
by Mariana Ortiz-Sanchez, Tatiana Agudelo-Patiño and Carlos Ariel Cardona Alzate
Processes 2024, 12(11), 2457; https://doi.org/10.3390/pr12112457 - 6 Nov 2024
Viewed by 1298
Abstract
Agroindustrial waste can be valorized towards the obtaining of several products such as pigments, proteins, fibers, and polyphenolic compounds with antioxidant capacity. Orange peel waste is a promising source of polyphenolic compounds such as hesperidin. However, conventional extraction techniques present some environmental limitations [...] Read more.
Agroindustrial waste can be valorized towards the obtaining of several products such as pigments, proteins, fibers, and polyphenolic compounds with antioxidant capacity. Orange peel waste is a promising source of polyphenolic compounds such as hesperidin. However, conventional extraction techniques present some environmental limitations such as high solvent consumption and high wastewater generation. Supercritical fluid extraction (SFE) has emerged as a green extraction technique due to the low use of solvent. The aim of this study was to maximize the hesperidin extraction based on theoretical predictions of the operating conditions from empirical thermodynamic models using SFE with carbon dioxide (CO2) as a solvent. The theoretical conditions were validated experimentally on a semi-pilot scale. The extracts were evaluated in terms of hesperidin content, total polyphenol content, and antioxidant capacity. Thermodynamic prediction of the operating conditions showed that the ethanol used as a co-solvent promotes hesperidin extraction. The optimum operating conditions were 25 °C, 80 bar, and a volumetric co-solvent concentration of 10%. The validation of the operating conditions resulted in a final hesperidin concentration of 11.5 ± 0.03 g/kg of orange peel waste. The experimental results were 30.26-times higher using 10% vol of ethanol than the extraction of hesperidin with pure ethanol as a co-solvent. The total polyphenol content and antioxidant capacity resulted in 831.92 ± 40.01 mg Galic acid/100 g orange peel waste, 15.41± 0.91 EC50/mL, and 5.31 ± 0.67 µMolTrox/100 g orange peel. Finally, the prediction of operating conditions from empirical thermodynamic models such as the Peng–Robinson equation of state with some modifications (Stryjek Vera) for solid–gas equilibrium solubility calculations, allows for maximizing the content of the polyphenolic compounds using SFE. Full article
(This article belongs to the Special Issue New Advances in Green Extraction Technology for Natural Products)
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