Special Issue "Advances in Biofabrication for Tissue Engineering and Regenerative Medicine Applications"

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Analysis".

Deadline for manuscript submissions: 5 February 2021.

Special Issue Editors

Dr. Marco Domingos
Website
Guest Editor
University of Manchester, Manchester, United Kingdom
Interests: biofabrication; functional materials; tissue engineering; regenerative medicine
Dr. Samuel Moxon
Website
Guest Editor
University of Manchester, Manchester, United Kingdom
Interests: tissue engineering; biopolymers; bioprinting; rheology; biomaterials; cell biology

Special Issue Information

Dear Colleagues

Biofabrication strategies, and in particular 3D bioprinting, continue to gain interest for the generation of high-fidelity tissue-engineered structures for regenerative medicine, disease modelling and drug discovery applications. A global research effort over the last few decades has led to considerable advances in both the capability of bioprinting platforms and the variety of biomaterials that can be used. Consequently, the market for 3D bioprinting technologies is predicted to reach in excess of $1.6 billion by 2024.

The constant innovation of bioprinting strategies has led to successful applications in a wide variety of healthcare applications. Advances are not, however, limited to improvements in the bioprinting platform itself. The design of appropriate biomaterial-based bioinks is equally essential to the generation of a successful strategy. The mechanical behavior of candidate materials should suit the bioprinting strategy whilst simultaneously not hindering the key cellular mechanisms that are essential in a particular application.

The aim of this Special Issue is to highlight new approaches in the biofabrication of biological structures including, but not limited to, the development of novel bioprinting strategies and the design of cutting-edge biomaterial systems.

Dr Marco Domingos and Dr Samuel Moxon

Guest Editors

Dr. Marco Domingos
Dr. Samuel Moxon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tissue engineering
  • regenerative medicine
  • biofabrication
  • bioprinting
  • 3D printing
  • biomaterials
  • polymers
  • bioinks

Published Papers (1 paper)

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Research

Open AccessArticle
A Preliminary Evaluation of the Pro-Chondrogenic Potential of 3D-Bioprinted Poly(ester Urea) Scaffolds
Polymers 2020, 12(7), 1478; https://doi.org/10.3390/polym12071478 - 30 Jun 2020
Abstract
Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity contributing to the development of more serious conditions such as [...] Read more.
Degeneration of articular cartilage (AC) is a common healthcare issue that can result in significantly impaired function and mobility for affected patients. The avascular nature of the tissue strongly burdens its regenerative capacity contributing to the development of more serious conditions such as osteoarthritis. Recent advances in bioprinting have prompted the development of alternative tissue engineering therapies for the generation of AC. Particular interest has been dedicated to scaffold-based strategies where 3D substrates are used to guide cellular function and tissue ingrowth. Despite its extensive use in bioprinting, the application of polycaprolactone (PCL) in AC is, however, restricted by properties that inhibit pro-chondrogenic cell phenotypes. This study proposes the use of a new bioprintable poly(ester urea) (PEU) material as an alternative to PCL for the generation of an in vitro model of early chondrogenesis. The polymer was successfully printed into 3D constructs displaying adequate substrate stiffness and increased hydrophilicity compared to PCL. Human chondrocytes cultured on the scaffolds exhibited higher cell viability and improved chondrogenic phenotype with upregulation of genes associated with type II collagen and aggrecan synthesis. Bioprinted PEU scaffolds could, therefore, provide a potential platform for the fabrication of bespoke, pro-chondrogenic tissue engineering constructs. Full article
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