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Article

3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering

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Department of Bioengineering, Faculty of Engineering, Marmara University, 34722 Istanbul, Turkey
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Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, 34722 Istanbul, Turkey
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Institute of Neurological Sciences, Marmara University, 34722 Istanbul, Turkey
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Department of Biochemistry, School of Medicine/Genetic and Metabolic Diseases Research and Investigation Center, Marmara University, 34722 Istanbul, Turkey
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Department of Metallurgy and Materials Engineering, Faculty of Technology, Marmara University, 34722 Istanbul, Turkey
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Department of Electrical and Electronics Engineering, Faculty of Technology, Marmara University, 34722 Istanbul, Turkey
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UCL Division of Surgery and Interventional Sciences, Royal Free Hospital Campus Rowland Hill Street, London NW3 2PF, UK
*
Authors to whom correspondence should be addressed.
Polymers 2020, 12(9), 1962; https://doi.org/10.3390/polym12091962
Received: 28 July 2020 / Revised: 26 August 2020 / Accepted: 26 August 2020 / Published: 29 August 2020
Three-dimensional (3D) printing application is a promising method for bone tissue engineering. For enhanced bone tissue regeneration, it is essential to have printable composite materials with appealing properties such as construct porous, mechanical strength, thermal properties, controlled degradation rates, and the presence of bioactive materials. In this study, polycaprolactone (PCL), gelatin (GEL), bacterial cellulose (BC), and different hydroxyapatite (HA) concentrations were used to fabricate a novel PCL/GEL/BC/HA composite scaffold using 3D printing method for bone tissue engineering applications. Pore structure, mechanical, thermal, and chemical analyses were evaluated. 3D scaffolds with an ideal pore size (~300 µm) for use in bone tissue engineering were generated. The addition of both bacterial cellulose (BC) and hydroxyapatite (HA) into PCL/GEL scaffold increased cell proliferation and attachment. PCL/GEL/BC/HA composite scaffolds provide a potential for bone tissue engineering applications. View Full-Text
Keywords: bacterial cellulose; gelatin; polycaprolactone; hydroxyapatite; 3D printing; bone tissue engineering bacterial cellulose; gelatin; polycaprolactone; hydroxyapatite; 3D printing; bone tissue engineering
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MDPI and ACS Style

Cakmak, A.M.; Unal, S.; Sahin, A.; Oktar, F.N.; Sengor, M.; Ekren, N.; Gunduz, O.; Kalaskar, D.M. 3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering. Polymers 2020, 12, 1962. https://doi.org/10.3390/polym12091962

AMA Style

Cakmak AM, Unal S, Sahin A, Oktar FN, Sengor M, Ekren N, Gunduz O, Kalaskar DM. 3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering. Polymers. 2020; 12(9):1962. https://doi.org/10.3390/polym12091962

Chicago/Turabian Style

Cakmak, Abdullah M.; Unal, Semra; Sahin, Ali; Oktar, Faik N.; Sengor, Mustafa; Ekren, Nazmi; Gunduz, Oguzhan; Kalaskar, Deepak M. 2020. "3D Printed Polycaprolactone/Gelatin/Bacterial Cellulose/Hydroxyapatite Composite Scaffold for Bone Tissue Engineering" Polymers 12, no. 9: 1962. https://doi.org/10.3390/polym12091962

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