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Open AccessArticle

Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges

1
PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Corso Duca Degli Abruzzi 29, 10129 Turin, Italy
2
Nanotechnology and Integrated Bio-Engineering Centre (NIBEC), Ulster University, Shore Road, Newtownabbey BT37 0QB, UK
*
Author to whom correspondence should be addressed.
Polymers 2020, 12(10), 2233; https://doi.org/10.3390/polym12102233
Received: 28 July 2020 / Revised: 16 September 2020 / Accepted: 18 September 2020 / Published: 28 September 2020
Reduced periodontal support, deriving from chronic inflammatory conditions, such as periodontitis, is one of the main causes of tooth loss. The use of dental implants for the replacement of missing teeth has attracted growing interest as a standard procedure in clinical practice. However, adequate bone volume and soft tissue augmentation at the site of the implant are important prerequisites for successful implant positioning as well as proper functional and aesthetic reconstruction of patients. Three-dimensional (3D) scaffolds have greatly contributed to solve most of the challenges that traditional solutions (i.e., autografts, allografts and xenografts) posed. Nevertheless, mimicking the complex architecture and functionality of the periodontal tissue represents still a great challenge. In this study, a porous poly(ε-caprolactone) (PCL) and Sr-doped nano hydroxyapatite (Sr-nHA) with a multi-layer structure was produced via a single-step additive manufacturing (AM) process, as a potential strategy for hard periodontal tissue regeneration. Physicochemical characterization was conducted in order to evaluate the overall scaffold architecture, topography, as well as porosity with respect to the original CAD model. Furthermore, compressive tests were performed to assess the mechanical properties of the resulting multi-layer structure. Finally, in vitro biological performance, in terms of biocompatibility and osteogenic potential, was evaluated by using human osteosarcoma cells. The manufacturing route used in this work revealed a highly versatile method to fabricate 3D multi-layer scaffolds with porosity levels as well as mechanical properties within the range of dentoalveolar bone tissue. Moreover, the single step process allowed the achievement of an excellent integrity among the different layers of the scaffold. In vitro tests suggested the promising role of the ceramic phase within the polymeric matrix towards bone mineralization processes. Overall, the results of this study demonstrate that the approach undertaken may serve as a platform for future advances in 3D multi-layer and patient-specific strategies that may better address complex periodontal tissue defects. View Full-Text
Keywords: polymer-based composites; multi-layer scaffold; single-step additive manufacturing; periodontal tissue engineering polymer-based composites; multi-layer scaffold; single-step additive manufacturing; periodontal tissue engineering
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MDPI and ACS Style

Porta, M.; Tonda-Turo, C.; Pierantozzi, D.; Ciardelli, G.; Mancuso, E. Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges. Polymers 2020, 12, 2233. https://doi.org/10.3390/polym12102233

AMA Style

Porta M, Tonda-Turo C, Pierantozzi D, Ciardelli G, Mancuso E. Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges. Polymers. 2020; 12(10):2233. https://doi.org/10.3390/polym12102233

Chicago/Turabian Style

Porta, Marta; Tonda-Turo, Chiara; Pierantozzi, Daniele; Ciardelli, Gianluca; Mancuso, Elena. 2020. "Towards 3D Multi-Layer Scaffolds for Periodontal Tissue Engineering Applications: Addressing Manufacturing and Architectural Challenges" Polymers 12, no. 10: 2233. https://doi.org/10.3390/polym12102233

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