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Polymers
Special Issues
Advances in Polymer Microfluidic Chips
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Advances in Polymer Microfluidic Chips

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (5 November 2023) | Viewed by 5282

Special Issue Editor

Dr. Yiqiang Fan

E-Mail Website
Guest Editor
School of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing 100029, China
Interests: polymer-based microfluidics; paper-based microfluidics; microfluidics injection molding
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymers have been widely used in the fabrication of microfluidic devices in recent decades. Compared with previous fabrication approaches using silicon or glass materials, polymer-based microfluidic devices have advantages in terms of cost, ease of processing, and suitability for massive production of microfluidic devices.

This Special Issue of the open access journal Polymers aims to collect cutting-edge original research papers and reviews on the topic of “Advances in Polymer Microfluidic Chips”, including but not limited to the following topics:

  • Novel design and simulation methods for polymer microfluidics;
  • Advanced microfabrication methods for polymer microfluidics;
  • Novel chemical/physical surface treatment method for polymer microfluidics;
  • Bonding methods for polymer microfluidics;
  • Massive production methods for polymer microfluidics, e.g., injection molding;
  • Integration of detection electrodes in polymer microfluidics;
  • Disinfect and storage studies on fabricated polymer microfluidic devices;
  • World-to-chip interface for polymer microfluidics;
  • Polymer microfluidics’ application in the biological, chemical, environmental, and energy fields.

It is my pleasure to invite researchers on polymer microfluidics to submit related manuscripts to this Special Issue.

Dr. Yiqiang Fan
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (3 papers)

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Research

11 pages, 3742 KiB  
Article
A Modular and Cost-Effective Droplet Microfluidic Device for Controlled Emulsion Production
by Hao Jiang, Zhaoyue Liu, Fengwei Tang, Yimin Cheng, Wei Tian, Woda Shi, Jia Ming Zhang and Yajun Zhang
Polymers 2024, 16(6), 765; https://doi.org/10.3390/polym16060765 - 11 Mar 2024
Viewed by 722
Abstract
The droplet microfluidic device has become a widely used tool in fields such as physics, chemistry, and biology, but its complexity has limited its widespread application. This report introduces a modular and cost-effective droplet microfluidic device for the controlled production of complex emulsions, [...] Read more.
The droplet microfluidic device has become a widely used tool in fields such as physics, chemistry, and biology, but its complexity has limited its widespread application. This report introduces a modular and cost-effective droplet microfluidic device for the controlled production of complex emulsions, including oil and aqueous single emulsions, and double emulsions with varying numbers of encapsulated droplets. The droplet sizes can be precisely controlled by easily replacing flat needles and adjusting the needle position within an axially accelerated co-flow field. This modular device not only allows for easy repair and maintenance in case of device clogging or damage but can also be readily expanded to produce complex emulsions. The low-cost and user-friendly nature of the device greatly facilitates the widespread adoption and utilization of droplet microfluidics. Full article
(This article belongs to the Special Issue Advances in Polymer Microfluidic Chips)
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18 pages, 4003 KiB  
Article
Bifurcated Asymmetric Field Flow Fractionation of Nanoparticles in PDMS-Free Microfluidic Devices for Applications in Label-Free Extracellular Vesicle Separation
by Miks Priedols, Gunita Paidere, Cristina Bajo Santos, Antons Miscenko, Romualds Gerulis Bergmanis, Arnita Spule, Beate Bekere, Gatis Mozolevskis, Arturs Abols and Roberts Rimsa
Polymers 2023, 15(4), 789; https://doi.org/10.3390/polym15040789 - 04 Feb 2023
Cited by 2 | Viewed by 1946
Abstract
Extracellular vesicles are small membrane-bound structures that are released by cells and play important roles in intercellular communication garnering significant attention in scientific society recently due to their potential as diagnostic and therapeutic tools. However, separating EVs from large-volume samples remains a challenge [...] Read more.
Extracellular vesicles are small membrane-bound structures that are released by cells and play important roles in intercellular communication garnering significant attention in scientific society recently due to their potential as diagnostic and therapeutic tools. However, separating EVs from large-volume samples remains a challenge due to their small size and low concentration. In this manuscript, we presented a novel method for separating polystyrene beads as control and extracellular vesicles from large sample volumes using bifurcated asymmetric field flow fractionation in PDMS-free microfluidic devices. Separation characteristics were evaluated using the control system of polystyrene bead mix, which offers up to 3.7X enrichment of EV-sized beads. Furthermore, in the EV-sample from bioreactor culture media, we observed a notable population distribution shift of extracellular vesicles. Herein presented novel PDMS-free microfluidic device fabrication protocol resulted in devices with reduced EV-loss compared to size-exclusion columns. This method represented an improvement over the current state of the art in terms of EV separation from large sample volumes through the use of novel field flow fractionation design. Full article
(This article belongs to the Special Issue Advances in Polymer Microfluidic Chips)
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15 pages, 8477 KiB  
Article
Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors
by Leire Etxeberria, Taha Messelmani, Jon Haitz Badiola, Andreu Llobera, Luis Fernandez, José Luis Vilas-Vilela, Eric Leclerc, Cécile Legallais, Rachid Jellali and Ane Miren Zaldua
Polymers 2022, 14(21), 4478; https://doi.org/10.3390/polym14214478 - 22 Oct 2022
Cited by 5 | Viewed by 1950
Abstract
Organ-on-chip (OoC) technology is one of the most promising in vitro tools to replace the traditional animal experiment-based paradigms of risk assessment. However, the use of OoC in drug discovery and toxicity studies remain still limited by the low capacity for high-throughput production [...] Read more.
Organ-on-chip (OoC) technology is one of the most promising in vitro tools to replace the traditional animal experiment-based paradigms of risk assessment. However, the use of OoC in drug discovery and toxicity studies remain still limited by the low capacity for high-throughput production and the incompatibility with standard laboratory equipment. Moreover, polydimethylsiloxanes, the material of choice for OoC, has several drawbacks, particularly the high absorption of drugs and chemicals. In this work, we report the development of a microfluidic device, using a process adapted for mass production, to culture liver cell line in dynamic conditions. The device, made of cyclic olefin copolymers, was manufactured by injection moulding and integrates Luer lock connectors compatible with standard medical and laboratory instruments. Then, the COC device was used for culturing HepG2/C3a cells. The functionality and behaviour of cultures were assessed by albumin secretion, cell proliferation, viability and actin cytoskeleton development. The cells in COC device proliferated well and remained functional for 9 days of culture. Furthermore, HepG2/C3a cells in the COC biochips showed similar behaviour to cells in PDMS biochips. The present study provides a proof-of-concept for the use of COC biochip in liver cells culture and illustrate their potential to develop OoC. Full article
(This article belongs to the Special Issue Advances in Polymer Microfluidic Chips)
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