Chemical Composition and Biological Activity of Plant Secondary Metabolites

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2178

Special Issue Editor

Department of Pharmacognosy, College of Pharmacy, Korea University, Sejong, Republic of Korea
Interests: metabolomic; natural product chemistry; phytochemistry; pharmacognosy; secondary metabolites; pharmacological effect

Special Issue Information

Dear Colleagues,

Natural compounds continue to play a pivotal role and serve as a source of inspiration for the development of novel drugs. Thus, natural products derived from plants and marine organisms have been extensively explored and studied for their therapeutic potential. The composition of natural products is rich and complex, consisting of compounds from various chemical classes, including low-molecular-weight volatile and semi-volatile compounds, as well as polar molecules that can modulate biological actions. Secondary metabolites show diverse pharmacological effects, such as antioxidant, anti-inflammatory, anti-tumor, anti-cancer, and cardiovascular effects. In this context, it is crucial to conduct suitable chemical characterization in order to identify and characterize the molecules potentially responsible for these effects.

This Special Issue aims to gather scientific papers on the pharmacological properties and chemical components of natural products. Therefore, we invite papers that discuss biological assays used to assess potential activities and investigative techniques for characterizing the chemical components of natural products.

Dr. Le Ba Vinh
Guest Editor

Manuscript Submission Information

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Keywords

  • natural product chemistry
  • phytochemistry
  • pharmacognosy
  • secondary metabolites
  • pharmacological effect
  • underlying mechanisms
  • NMR, GC-MS
  • LC-MS
  • quantitative analysis
  • inflammation
  • anti-cancer

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Published Papers (1 paper)

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Research

13 pages, 21882 KiB  
Article
Two New Steroidal Saponins with Potential Anti-Inflammatory Effects from the Aerial Parts of Gnetum formosum Markgr.
by Ngo Van Hieu, Le Ba Vinh, Nguyen Viet Phong, Pham Van Cong, Nguyen Tien Dat, Nguyen Van Dan, Ngo Viet Duc, Hoang Minh Tao, Le Thi Tam, Le Tuan Anh, Nguyen Cao Cuong, Bui Huu Tai, Seo Young Yang and Hoang Le Tuan Anh
Plants 2024, 13(15), 2100; https://doi.org/10.3390/plants13152100 - 29 Jul 2024
Cited by 2 | Viewed by 1540
Abstract
Gnetum formosum Markgr., a member of the Gnetaceae family, is distributed in Vietnam. This plant remains a botanical enigma with an unexplored diversity of chemical constituents and pharmacological effects. In this study, two new steroidal saponins, namely gnetumosides A (1) and [...] Read more.
Gnetum formosum Markgr., a member of the Gnetaceae family, is distributed in Vietnam. This plant remains a botanical enigma with an unexplored diversity of chemical constituents and pharmacological effects. In this study, two new steroidal saponins, namely gnetumosides A (1) and B (2), were isolated from the aerial parts of G. formosum. Their chemical structures were elucidated using spectroscopic techniques, including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) and NMR, along with chemical hydrolysis and comparison with the reported literature. The potential anti-inflammatory effects of the isolated compounds were evaluated by measuring lipopolysaccharide-stimulated nitric oxide (NO) production in murine macrophage cells. Notably, compound 1 exhibited the most potent inhibitory activity (IC50 = 14.10 ± 0.75 µM), comparable to dexamethasone. Additionally, the mechanisms underlying the observed anti-inflammatory effects were investigated through molecular docking and molecular dynamics simulations on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) proteins. This study is the first to investigate the chemical constituents and pharmacological effects of G. formosum. Full article
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