Production, Sorting, and Accumulation of Proteins and Metabolites within Plant Cells

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Plant Cell Biology".

Deadline for manuscript submissions: closed (20 November 2022) | Viewed by 3427

Special Issue Editors


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Guest Editor
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, LE, Italy
Interests: endomembrane trafficking; unconventional routes; metabolites and xenobiotics compartmentalization; biostimulation
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
GreenUPorto - Sustainable Agrifood Production Research Centre/Inov4Agro – Faculty of Sciences, University of Porto - Rua do Campo Alegre, s/nº, 4169-007 Porto, Portugal
Interests: vacuolar sorting; vacuole biogenesis; sorting signals; endomembranes; trafficking; abiotic stress; plant specific insert
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The use of plants as biofactories for the production of natural compounds has a long tradition and is today attracting new attention for a higher awareness of the value of plant biomasses in a circular economy. Moreover, in recent years, plant-based bioproduction platforms have emerged as promising strategies to produce recombinant proteins, offering very low production costs and unbeatable scalability. The production of recombinant pharmaceutical proteins is a hot topic in biotechnology as plants are clearly an advantageous expression system when compared with their more commonly used microbial and mammalian cell-culture-based counterparts, offering much lower production costs, low risk of human and animal pathogen contaminations, and unbeatable scalability.

Membrane trafficking carries out transport of all the molecules of possible interest, from their synthesis to accumulation, and requires the coordination of multiple signaling events and molecular motors to control cargo sorting. A better understanding of the secretory pathway in plants can drive improvements in food production and plant-based products with medicinal, nutritional, and commercial value. Moreover, the complex endomembrane system ensures metabolite compartmentalization and stability. The secretory pathway of plants is perfect for both producing proteins that undergo complex post-translational modifications to become pharmacologically functional and directing the foreign protein to a particular subcellular compartment for further purification or storage.

This Special Issue offers a unique opportunity to bring together information for an up-to-date approach to molecular biology and biotechnology, where the biological system is optimized for the production or accumulation of high-value products. At the same time, it will have a great impact in the endomembrane trafficking community as it aims to explore an open problem with constant new updates given the number of new mechanisms, effectors, and pathways being disclosed today.

Prof. Dr. Gian-Pietro Di Sansebastiano
Dr. Cláudia Sofia Pereira
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endomembrane system
  • protein sorting
  • plant metabolites
  • biotechnology
  • natural products accumulation
  • secondary metabolism
  • compartmentalization
  • bioproduction

Published Papers (1 paper)

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Review

34 pages, 2934 KiB  
Review
Xanthones: Biosynthesis and Trafficking in Plants, Fungi and Lichens
by Camilla Badiali, Valerio Petruccelli, Elisa Brasili and Gabriella Pasqua
Plants 2023, 12(4), 694; https://doi.org/10.3390/plants12040694 - 4 Feb 2023
Cited by 9 | Viewed by 3007
Abstract
Xanthones are a class of secondary metabolites produced by plant organisms. They are characterized by a wide structural variety and numerous biological activities that make them valuable metabolites for use in the pharmaceutical field. This review shows the current knowledge of the xanthone [...] Read more.
Xanthones are a class of secondary metabolites produced by plant organisms. They are characterized by a wide structural variety and numerous biological activities that make them valuable metabolites for use in the pharmaceutical field. This review shows the current knowledge of the xanthone biosynthetic pathway with a focus on the precursors and the enzymes involved, as well as on the cellular and organ localization of xanthones in plants. Xanthone biosynthesis in plants involves the shikimate and the acetate pathways which originate in plastids and endoplasmic reticulum, respectively. The pathway continues following three alternative routes, two phenylalanine-dependent and one phenylalanine-independent. All three routes lead to the biosynthesis of 2,3′,4,6-tetrahydroxybenzophenone, which is the central intermediate. Unlike plants, the xanthone core in fungi and lichens is wholly derived from polyketide. Although organs and tissues synthesizing and accumulating xanthones are known in plants, no information is yet available on their subcellular and cellular localization in fungi and lichens. This review highlights the studies published to date on xanthone biosynthesis and trafficking in plant organisms, from which it emerges that the mechanisms underlying their synthesis need to be further investigated in order to exploit them for application purposes. Full article
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