Applications of Omics and Bioinformatics in Medicinal Plants

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 520

Special Issue Editors


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Guest Editor
1. College of Life Science, Jilin Agricultural University, Changchun 130118, China
2. Jilin Engineering Research Center Ginseng Genetic Resources Development and Utilization, Changchun 130118, China
Interests: plant genome; transcription factor family; functional genomics; methyl jasmonate treatment

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CQM—Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal
Interests: chemical composition of aromatic, medicinal, and food plants; organic chemistry hemi synthesis of bioactive compounds using natural products as raw materials; assessment of the biological activity of new compounds
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Special Issue Information

Dear Colleagues,

Medicinal plants have historically served as a fundamental component of both traditional and contemporary medicine, offering a substantial reservoir of bioactive compounds for disease treatment and health promotion. However, realizing their full potential necessitates the use of advanced methodologies to unravel their intricate biochemical pathways, genetic diversity, and ecological interactions. This Special Issue examines the transformative impact of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and bioinformatics, on advancing medicinal plant research. These state-of-the-art approaches facilitate comprehensive investigations of plant systems, such as gene-to-metabolite networks, thereby fostering innovations in drug discovery, sustainable cultivation, and conservation. The integration of omics technologies has enabled researchers to identify key genes involved in the biosynthesis of pharmacologically active compounds, such as alkaloids, terpenoids, and phenolics; optimize metabolic engineering strategies; and enhance plants’ resilience to environmental stressors. We welcome submissions of original research, reviews, and methodological advancements to provide a platform to promote collaboration among biologists, bioinformaticians, pharmacologists, and agronomists. Submitted manuscripts must not be previously published or under evaluation for publication in another journal.

Dr. Kangyu Wang
Dr. Paula C. Castilho
Guest Editors

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Keywords

  • bioinformatics
  • medicinal plants
  • genomics
  • transcriptomics
  • proteomics
  • metabolomics
  • gene family
  • transcription factor

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Published Papers (1 paper)

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Research

19 pages, 2879 KiB  
Article
Metabolomic Insights into Sexual Multi-Morphism of Sinomenine Accumulation in Sinomenium acutum
by Yanxian Luo, Wen Xu, Yanling Fan, Xinyu Ma, Qian Deng, Meng Li and Wei Sun
Plants 2025, 14(12), 1885; https://doi.org/10.3390/plants14121885 - 19 Jun 2025
Viewed by 362
Abstract
Sinomenium acutum is the main raw material for sinomenine. Empirical evidence indicates a marked disparity in sinomenine content among S. acutum plants with different genders, resulting in varying medicinal potential of the processing products. However, the mechanism underlying gender-determined differences in sinomenine accumulation [...] Read more.
Sinomenium acutum is the main raw material for sinomenine. Empirical evidence indicates a marked disparity in sinomenine content among S. acutum plants with different genders, resulting in varying medicinal potential of the processing products. However, the mechanism underlying gender-determined differences in sinomenine accumulation is still elusive. In this study, untargeted metabolomics was performed among female, male, and undifferentiated S. acutum plants. In total, 1213 metabolites were identified, and most of them vary in the roots but not in the leaves among the different genders. Integrated correlation analysis on the DAMs (differentially accumulated metabolites) enriched in the isoquinoline alkaloid biosynthesis pathway suggests coclaurine as an intermediate determining gender-dependent sinomenine variation. Furthermore, hormonal profiling revealed 34 endogenous phytohormones exhibiting significant gender-based discrepancy in the roots. Among these, ABA (abscisic acid) and 5-DS (5-deoxystrigol) show significant positive correlation with sinomenine content. Then, exogenous ABA with gradient concentration was applied on S. acutum plants, and the sinomenine content in the roots increased from 31% to 166% under treatment. Our findings demonstrate that coclaurine might serve as a pivotal intermediate during sinomenine biosynthesis in S. acutum. Meanwhile, it is speculated that ABA is a key factor regulating different sinomenine accumulation, which provide a potential method to improve the yield of sinomenine. Full article
(This article belongs to the Special Issue Applications of Omics and Bioinformatics in Medicinal Plants)
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