Phytochemical Compounds and Antioxidant Properties of Plants

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 2237

Special Issue Editor


E-Mail Website
Guest Editor
Department Biology, Multidisciplinary Faculty of Nador, Nador 62702, Morocco
Interests: antioxidant activity; natural products; bioactive compounds; phytochemistry; natural product chemistry; HPLC analysis; plyphenols; essential oils

Special Issue Information

Dear Colleagues,

Phytochemical compounds are essential bioactive molecules found in plants, playing a crucial role in their defense mechanisms against environmental stressors, pathogens, and herbivores, while simultaneously offering substantial benefits for human health. Among their many biological activities, antioxidant properties stand out due to their potential health benefits and diverse applications in medical, food, pharmaceutical, and cosmetic industries.

Recent advances in analytical techniques have revolutionized our understanding of the structural diversity and biological activities of plant antioxidants, including polyphenols, flavonoids, carotenoids, alkaloids, and terpenes.

This Special Issue aims to explore recent advances in the identification, characterization, and utilization of plant-derived phytochemicals with antioxidant properties.

We welcome original research, review articles, and short communications covering various aspects, including, but not limited to, the following:

  • Extraction, isolation, and characterization of antioxidant phytochemicals.
  • Molecular mechanisms underlying their antioxidant activity.
  • Advanced extraction and analytical methods for plant antioxidants.
  • Potential applications in food preservation, pharmaceuticals, and cosmetics.
  • Bioavailability and metabolism of plant antioxidants in humans.
  • Sustainable production and green extraction of plant antioxidants.
  • Traditional knowledge and ethnobotanical approaches to antioxidant-rich plants.
  • The role of phytochemicals in plant defense and stress responses.

By gathering cutting-edge research in this field, we hope to provide a comprehensive understanding of plant-based antioxidants and their impact on human health and sustainable agriculture.

I look forward to your contributions.

Prof. Dr. Smail Aazza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemical compounds
  • antioxidant activity
  • oxidative stress
  • health benefits
  • chronic disease management
  • analytical techniques
  • plant metabolomics
  • medicinal plants
  • functional foods
  • food preservation
  • polyphenols
  • essential oils
  • pharmaceutical applications
  • cosmetics
  • anti-aging
  • skincare

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

23 pages, 2945 KB  
Article
Application of 1H NMR and HPLC-DAD in Metabolic Profiling of Extracts of Lavandula angustifolia and Lavandula × intermedia Cultivars
by Natalia Dobros, Katarzyna Zawada, Łukasz Woźniak and Katarzyna Paradowska
Plants 2026, 15(2), 217; https://doi.org/10.3390/plants15020217 - 10 Jan 2026
Cited by 1 | Viewed by 559
Abstract
NMR spectroscopy enables the study of complex mixtures, including plant extracts. The interpretation of specific ranges of 1H NMR spectra allows for the determination of polyphenolic compound, sugar, amino acid, and fatty acid profiles. The main goal of 1H NMR analyses [...] Read more.
NMR spectroscopy enables the study of complex mixtures, including plant extracts. The interpretation of specific ranges of 1H NMR spectra allows for the determination of polyphenolic compound, sugar, amino acid, and fatty acid profiles. The main goal of 1H NMR analyses of plant extracts is to identify the unique “fingerprint” of the material being studied. The aim of this study was to determine the metabolomic profile and antioxidant activity of various Lavandula angustifolia (Betty’s Blue, Elizabeth, Hidcote, and Blue Mountain White) and Lavandula × intermedia cultivars (Alba, Grosso, and Gros Bleu) grown in Poland. Modern green chemistry extraction methods (supercritical fluid extraction (SFE) and ultrasound-assisted extraction (UAE)) were used to prepare the lipophilic and hydrophilic extracts, respectively. The secondary metabolite profiles were determined using the diagnostic signals from 1H NMR and HPLC-DAD analyses. These metabolomic profiles were used to illustrate the differences between the different lavender and lavandin cultivars. The HPLC-DAD analysis revealed that both lavender species have similar polyphenolic profiles but different levels of individual compounds. The extracts from L. angustifolia were characterized by higher phenolic acid and flavonoid contents, while the extracts from L. × intermedia had a higher coumarin content. Diagnostic 1H NMR signals can be used to verify the authenticity and origin of plant extracts, and identify directions for further research, providing a basis for applications such as in cosmetics. Full article
(This article belongs to the Special Issue Phytochemical Compounds and Antioxidant Properties of Plants)
Show Figures

Figure 1

33 pages, 5246 KB  
Article
Mechanisms Underlying the Cognitive Benefits of Solanum macrocarpon Leaf n-Butanol Extract: Acetylcholinesterase Inhibition and Oxidative Stress Modulation
by Ion Brinza, Ibukun Oluwabukola Oresanya, Ilkay Erdogan Orhan, Hasya Nazlı Gök, Lucian Hritcu and Razvan Stefan Boiangiu
Plants 2025, 14(21), 3283; https://doi.org/10.3390/plants14213283 - 27 Oct 2025
Viewed by 1059
Abstract
This study investigates the neuroprotective and anxiolytic effects of Solanum macrocarpon L. leaf n-butanol extract (SMB) in a zebrafish model of scopolamine (SCOP; 100 μM)-induced cognitive and behavioral impairments. SCOP, a muscarinic receptor antagonist, is commonly used to mimic memory deficits and anxiety-like [...] Read more.
This study investigates the neuroprotective and anxiolytic effects of Solanum macrocarpon L. leaf n-butanol extract (SMB) in a zebrafish model of scopolamine (SCOP; 100 μM)-induced cognitive and behavioral impairments. SCOP, a muscarinic receptor antagonist, is commonly used to mimic memory deficits and anxiety-like behaviors associated with neurodegenerative conditions. Zebrafish were chronically exposed to SMB at concentrations of 1, 3, and 6 mg/L. Behavioral assessments included anxiety-related paradigms, such as novel tank diving (NTT), novel approach (NA), and light–dark transition (LD) tests, as well as cognitive assays, including the Y-maze and novel object recognition (NOR) tests. SMB significantly mitigated SCOP-induced anxiety-like behaviors and cognitive deficits in a dose-dependent manner. Biochemical analyses demonstrated that SMB inhibited acetylcholinesterase (AChE) overactivity, indicating restoration of cholinergic function. Furthermore, SMB enhanced the activity of endogenous antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPX) and significantly reduced oxidative stress biomarkers, including malondialdehyde (MDA) and protein carbonyls. These findings suggest that SMB may exert neuroprotective effects through modulation of cholinergic signaling and oxidative stress. Overall, SMB represents a promising phytotherapeutic candidate for mitigating cognitive and anxiety-related symptoms linked to oxidative damage. Further investigations are warranted to characterize its active constituents and assess long-term efficacy and safety in models of neurodegeneration. Full article
(This article belongs to the Special Issue Phytochemical Compounds and Antioxidant Properties of Plants)
Show Figures

Figure 1

Back to TopTop