Special Issue "Pharmaceutical Industry 4.0"

A special issue of Pharmacy (ISSN 2226-4787).

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Assoc. Prof. Dr. Dimitrios M. Rekkas
Guest Editor
Department of Pharmacy, National and Kapodistrian University of Athens, Athens 15784, Greece
Interests: pharmaceutical technology; industrial pharmacy; dosage form design; experimental design; statistical process control; quality control; quality assurance; total quality management; quality by design (QbD)
Dr. Panorios Benardos
Co-Guest Editor
School of Mechanical Engineering, National Technical University of Athens, Zografou, Athens, GR15780, Greece
Interests: computer aided manufacturing (CAM), design of experiments (DoE), modelling and optimisation of manufacturing processes and systems, robotic applications in manufacturing processes and systems, artificial intelligence, machine learning, machine vision, data analytics, industrial internet of things (IIoT)

Special Issue Information

Dear Colleagues,

The pharmaceutical industry is under a major change in light of specific regulatory, scientific, and technological advancements. Following a long period of inaction, the pharmaceutical industry faced the first wave of change mainly originating from the regulatory authorities. The FDA’s new quality initiatives started during the 1990s and focused on process engineering, introduced novel approaches for Pharma such as systems thinking in GMPs, quality by design, pharmaceutical quality system, quality risk management, continuous manufacturing, etc. This wave shaped a totally new regulatory framework, which significantly disrupted Pharma’s old culture regarding, among others, its outdated manufacturing methodologies and empirical development practices. Consequently, and more recently, the Industry 4.0 wave of change impacted deeper the traditional ways the Pharma Industry was adopting in its supply chain, research, manufacturing, and business practices. AI/ML, Big Data, precision medicine, digitalization, smart factories, 3D printing, just to name a few, require totally new knowledge and skills for the Pharma’s work force. This Special Issue will present in detail all these technological breakthroughs, which when taken as a whole, will eventually reflect the pillars of the Pharmaceutical Industry 4.0 paradigm which is under way.

Assoc. Prof. & Head Dimitrios M. Rekkas
Dr. Panorios Benardos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmacy is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Pharma industry 4.0
  • Bioprocess technology & engineering
  • The smart factory
  • Digital therapeutics
  • AI and machine learning in the pharmaceutical industry
  • The new manufacturing paradigm within the QbD framework
  • Technology or knowledge transfer?
  • The new era of precision medicine and e-clinical trials
  • Digital twins technology
  • 3D printing
  • The new architecture of the pharmaceutical supply chains

Published Papers

This special issue is now open for submission.
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