Special Issue "Respiratory and Nasal Drug Delivery"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (20 December 2013).
Novel developments in the fields of Biotechnology and Combinatorial Chemistry rekindled overall interest in exploring the respiratory and nasal routes for systemic delivery of biomolecules (e.g., proteins, peptides and nucleic acids). Pursuits in these areas of drug delivery are not limited to macromolecules and systemic delivery. Many research groups are consistently looking for more effective ways to deliver small molecules local to the lung, nasal sinuses and brain via the nasal route. Novel approaches for efficient systemic and local drug delivery have been developed over the past few years. Such strategies include novel formulations (micro/nano particles, stent) and delivery devices. Successful respiratory and nasal drug delivery also requires sound experimental methods/model development. This special issue entitled: "Respiratory and Nasal Drug Delivery" will deal with key aspects of modern respiratory and nasal delivery. Micro-/nano-particulate delivery; formulation/delivery of aerosols and dry powders; optimization of nasal and respiratory drug absorption using in vitro, ex vivo and in situ tissue culture and animal models; brain targeting via the nasal route; exploration of mechanisms of epithelial drug permeation (e.g., active transport mechanisms); aerosol delivery simulation and other particle projectile studies; toxicological aspects of nasal and respiratory drug delivery, especially micro and nanoparticles; pharmacodynamics and pharmacokinetics of novel formulations following nasal and inhalational administration will be covered. Other relevant topics including muco-/bio-adhesive delivery, cilio-toxicity screening, delivery devices development, optimization and validation are also welcomed.
Dr. Remigius U. Agu
Manuscript Submission Information
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- drug delivery
- drug targeting