Cyclodextrins in Drug Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 31675
Special Issue Editors
Interests: cyclodextrins complexes; dissolution; nanocarriers as drug delivery systems; drug-in cyclodextrin-in nanocarrier; transmucosal delivery
Special Issues, Collections and Topics in MDPI journals
Interests: cyclodextrins; drug delivery systems; drug-in-cyclodextrin-in-nanolipid carriers; oral administration; pediatric formulations; topical delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cyclodextrins are one of the most versatile tools in pharmaceutical technology, due to their unique structural conformation. They are cyclic oligosaccharides consisting of (α-1,4-)-linked α-D-glucopyranose units with a hydrophilic outer surface and a hydrophobic central cavity, able to form non-covalent inclusion complexes with a wide range of molecules, including a variety of drugs. They are also able to form a variety of supramolecular structures (self-assembling systems, poly(pseudo)rotaxanes, cross-linked networks). Moreover, natural cyclodextrins can be opportunely derivatized and/or functionalized to further extend and enhance their possible applications.
Cyclodextrins play a very important role in formulation by improving drug solubility and/or dissolution, permeability, and physical and chemical stability, thus enhancing their bioavailability. Other applications include odor and taste masking, prevention of incompatibility, and control of drug release.
Moreover, their combined use with various nanocarriers can be an interesting approach to simultaneously increase the performance of both as drug carriers.
Due to their multifunctional properties, cyclodextrins can be exploited in the development of almost every kind of drug delivery system, aimed for oral, transdermal, parenteral, ocular, nasal, or rectal administration.
Authors are kindly invite to submit original papers, communications and reviews regarding potential applications of cyclodextrins in drug delivery, to be published in this Special Issue of Pharmaceutics.
Prof. Dr. Paola Mura
Prof. Dr. Marzia Cirri
Guest Editors
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Keywords
- cyclodextrins
- drug delivery
- inclusion complexes
- supramolecular structures
- drug-in cyclodextrin-in nanocarrier
- solubility
- stability
- bioavailability
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Related Special Issue
- Cyclodextrins in Drug Delivery, 2nd Edition in Pharmaceutics (5 articles)