Special Issue "Cyclodextrins in Drug Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editors

Prof. Dr. Paola Mura
E-Mail Website
Guest Editor
Department of Chemistry, Florence University, via Schiff 6, Sesto Fiorentino, Florence, Italy
Interests: cyclodextrins complexes; dissolution; nanocarriers as drug delivery systems; drug-in cyclodextrin-in nanocarrier; transmucosal delivery
Prof. Dr. Marzia Cirri
E-Mail Website
Guest Editor
Department of Chemistry, University of Florence, via Schiff 6, Sesto Fiorentino, 50019 Florence, Italy.
Interests: cyclodextrins; drug delivery systems; drug-in-cyclodextrin-in-nanolipid carriers; oral administration; pediatric formulations; topical delivery
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Special Issue Information

Dear Colleagues,

Cyclodextrins are one of the most versatile tools in pharmaceutical technology, due to their unique structural conformation. They are cyclic oligosaccharides consisting of (α-1,4-)-linked α-D-glucopyranose units with a hydrophilic outer surface and a hydrophobic central cavity, able to form non-covalent inclusion complexes with a wide range of molecules, including a variety of drugs. They are also able to form a variety of supramolecular structures (self-assembling systems, poly(pseudo)rotaxanes, cross-linked networks). Moreover, natural cyclodextrins can be opportunely derivatized and/or functionalized to further extend and enhance their possible applications.

Cyclodextrins play a very important role in formulation by improving drug solubility and/or dissolution, permeability, and physical and chemical stability, thus enhancing their bioavailability. Other applications include odor and taste masking, prevention of incompatibility, and control of drug release.

Moreover, their combined use with various nanocarriers can be an interesting approach to simultaneously increase the performance of both as drug carriers.

Due to their multifunctional properties, cyclodextrins can be exploited in the development of almost every kind of drug delivery system, aimed for oral, transdermal, parenteral, ocular, nasal, or rectal administration.

Authors are kindly invite to submit original papers, communications and reviews regarding potential applications of cyclodextrins in drug delivery, to be published in this Special Issue of Pharmaceutics.

Prof. Dr. Paola Mura
Prof. Dr. Marzia Cirri
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cyclodextrins
  • drug delivery
  • inclusion complexes
  • supramolecular structures
  • drug-in cyclodextrin-in nanocarrier
  • solubility
  • stability
  • bioavailability

Published Papers (2 papers)

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Research

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Open AccessArticle
Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
Pharmaceutics 2021, 13(2), 261; https://doi.org/10.3390/pharmaceutics13020261 - 15 Feb 2021
Cited by 1 | Viewed by 631
Abstract
Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding [...] Read more.
Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection. Full article
(This article belongs to the Special Issue Cyclodextrins in Drug Delivery)
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Review

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Open AccessReview
Cyclodextrin-Based Supramolecular Complexes of Osteoinductive Agents for Dental Tissue Regeneration
Pharmaceutics 2021, 13(2), 136; https://doi.org/10.3390/pharmaceutics13020136 - 21 Jan 2021
Viewed by 422
Abstract
Oral tissue regeneration has received growing attention for improving the quality of life of patients. Regeneration of oral tissues such as alveolar bone and widely defected bone has been extensively investigated, including regenerative treatment of oral tissues using therapeutic cells and growth factors. [...] Read more.
Oral tissue regeneration has received growing attention for improving the quality of life of patients. Regeneration of oral tissues such as alveolar bone and widely defected bone has been extensively investigated, including regenerative treatment of oral tissues using therapeutic cells and growth factors. Additionally, small-molecule drugs that promote bone formation have been identified and tested as new regenerative treatment. However, treatments need to progress to realize successful regeneration of oral functions. In this review, we describe recent progress in development of regenerative treatment of oral tissues. In particular, we focus on cyclodextrin (CD)-based pharmaceutics and polyelectrolyte complexation of growth factors to enhance their solubility, stability, and bioactivity. CDs can encapsulate hydrophobic small-molecule drugs into their cavities, resulting in inclusion complexes. The inclusion complexation of osteoinductive small-molecule drugs improves solubility of the drugs in aqueous solutions and increases in vitro osteogenic differentiation efficiency. Additionally, various anionic polymers such as heparin and its mimetic polymers have been developed to improve stability and bioactivity of growth factors. These polymers protect growth factors from deactivation and degradation by complex formation through electrostatic interaction, leading to potentiation of bone formation ability. These approaches using an inclusion complex and polyelectrolyte complexes have great potential in the regeneration of oral tissues. Full article
(This article belongs to the Special Issue Cyclodextrins in Drug Delivery)
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