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Article

Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

1
Laboratorio de Nanoquímica y Química Supramolecular, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago 7800003, Chile
2
Laboratorio de Nanobiotecnología y Nanotoxicología, Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380000, Chile
3
Advanced Center for Chronic Diseases (ACCDiS), Universidad de Chile and Pontificia Universidad Católica de Chile, Santiago 8380000, Chile
4
Laboratorio de Química teórica, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago 7800003, Chile
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Laboratorio de Espectroscopía Vibracional, Departamento de Química, Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, Ñuñoa, Santiago 7800003, Chile
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Instituto de Nanociencia y Materiales de Aragón (INMA), CSIC-Universidad de Zaragoza, 50009 Zaragoza, Spain
7
Laboratorio de Biosensores, Departamento de Química Farmacológica y Toxicológica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Santos Dumont 964, Independencia, Santiago 8380000, Chile
*
Authors to whom correspondence should be addressed.
Academic Editor: Paola Mura
Pharmaceutics 2021, 13(2), 261; https://doi.org/10.3390/pharmaceutics13020261
Received: 13 January 2021 / Revised: 8 February 2021 / Accepted: 10 February 2021 / Published: 15 February 2021
(This article belongs to the Special Issue Cyclodextrins in Drug Delivery)
Gold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic β-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV–VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 ± 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection. View Full-Text
Keywords: gold nanostars; cationic β-cyclodextrin-based polymer; phenylethylamine; piperine; drug co-loading; surface-enhanced Raman scattering gold nanostars; cationic β-cyclodextrin-based polymer; phenylethylamine; piperine; drug co-loading; surface-enhanced Raman scattering
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MDPI and ACS Style

Donoso-González, O.; Lodeiro, L.; Aliaga, Á.E.; Laguna-Bercero, M.A.; Bollo, S.; Kogan, M.J.; Yutronic, N.; Sierpe, R. Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring. Pharmaceutics 2021, 13, 261. https://doi.org/10.3390/pharmaceutics13020261

AMA Style

Donoso-González O, Lodeiro L, Aliaga ÁE, Laguna-Bercero MA, Bollo S, Kogan MJ, Yutronic N, Sierpe R. Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring. Pharmaceutics. 2021; 13(2):261. https://doi.org/10.3390/pharmaceutics13020261

Chicago/Turabian Style

Donoso-González, Orlando, Lucas Lodeiro, Álvaro E. Aliaga, Miguel A. Laguna-Bercero, Soledad Bollo, Marcelo J. Kogan, Nicolás Yutronic, and Rodrigo Sierpe. 2021. "Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring" Pharmaceutics 13, no. 2: 261. https://doi.org/10.3390/pharmaceutics13020261

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