Physiologically-Based Pharmacokinetics (PBPK) and Biopharmaceutics (PBBM) Modeling

Dear Colleagues,

Physiologically based pharmacokinetic (PBPK) modelling as a valuable tool for model informed drug discovery and development process, gaining recognition by the main regulatory authorities for drug approval because of their strength in data integration, mechanistic perspective and superior predictive power. Physiologically based biopharmaceutic (PBBM) models cover a recent field of research by the integration of in vitro dissolution experiments into PBPK models to predict the behaviour of the oral formulation in vivo and verifying whether the dissolution method of the pharmaceutical product is biopredictive or clinically relevant. Both model-informed strategies (PBPK and PBBM) contribute to optimise the drug development and use of medicines.

The aim of this Special Issue is to highlight recent advances in all aspects relevant to PBPK and PBBM modelling from the early drug discovery to beyond phase III clinical trials as well as its application in the clinic aimed at achieving an optimal dosage regimen. Additionally, regulatory and academic applications showing the impact in drug’s approval and solving theoretical aspects using PBPK or PBBM models are also welcome.

Dr. Matilde Merino-Sanjuán
Dr. Virginia Merino Sanjuán
Dr. Victor Mangas Sanjuán
Guest Editors

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