Anticancer Nanotherapeutics for Lung Cancer Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 July 2026 | Viewed by 1207

Special Issue Editors


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Guest Editor
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China
Interests: cocrystal; crystal engineering; ionic liquid drug delivery systems

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Guest Editor
School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China
Interests: antitumor nanomedicine; ROS-mediated tumor oxidation therapy; ROS-responsive prodrug/nanodrug delivery; ROS-mediated immunotherapy; ROS-mediated combination therapy; advanced targeted drug delivery system with nanomedicine or macrophage; ROS-responsive hydrogel
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Special Issue Information

Dear Colleagues,

Lung cancer has become one of the major types of cancers threatening the health and life of humankind, with continuously growing mortality and morbidity. The pharmaceutical sector has made many efforts to combat lung cancer, and a series of novel therapeutics have been developed. Among nanotherapeutics, those that shed light on their superior drug loading and delivery attributes are particularly noteworthy. Nanotherapeutics refer to nanosystems in which therapeutic agents are encapsulated or attached to nanoparticles, such as liposomes, polymeric micelles, and nanogels. Most importantly, they are asserted to possess enhanced targeting functions over conventional therapeutics, due to the passive or active targeting abilities. The relevant topics are hotspots in the current scientific community, which attract research interests from all over the world. 

This Special Issue aims to welcome impressive contributions (articles, reviews, communications, etc.) on anticancer nanotherapeutics for lung cancer therapy. The Guest Editor team believes that input from global scientists can contribute to the understanding of nanotherapeutics design and development, and accelerate the advancement of lung cancer treatment. Nanomedicines intended for pulmonary delivery will be especially encouraged because of the pathological nature of lung cancer, while targeting nanosystems delivered by other routes are also considered. We look forward to your contributions.

Dr. Zhengwei Huang
Dr. Xialin Dai
Dr. Yanjuan Huang
Guest Editors

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Keywords

  • lung cancer
  • nanotherapeutics
  • nanoparticles
  • liposomes
  • polymeric micelles
  • nanogels
  • targeting nanosystems
  • pulmonary delivery

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Published Papers (1 paper)

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Research

22 pages, 7468 KB  
Article
Pulmonary Delivery of Inhalable Sustained Release Nanocomposites Microparticles Encapsulating Osimertinib for Non-Small Cell Lung Cancer Therapy
by Iman M. Alfagih, Alanood Almurshedi, Basmah Aldosari, Bushra Alquadeib, Baraa Hajjar, Hafsa Elwali, Hadeel ALtukhaim, Eman Alzahrani, Sara Alhumaidan and Ghaida Alharbi
Pharmaceutics 2026, 18(1), 134; https://doi.org/10.3390/pharmaceutics18010134 - 21 Jan 2026
Viewed by 909
Abstract
Background/Objective: Osimertinib (OSI) is a third-generation tyrosine kinase inhibitor approved for non-small cell lung cancer (NSCLC) therapy. OSI is administered orally; this route limits the amount of OSI reaching the tumor in the lungs and is associated with serious systemic toxicity. This study [...] Read more.
Background/Objective: Osimertinib (OSI) is a third-generation tyrosine kinase inhibitor approved for non-small cell lung cancer (NSCLC) therapy. OSI is administered orally; this route limits the amount of OSI reaching the tumor in the lungs and is associated with serious systemic toxicity. This study aimed to develop a dry powder inhalable formulation to provide tumor-targeted delivery and minimize systemic toxicity. To the best of our knowledge, this is the first study to prepare and evaluate a dry powder inhalation formulation of OSI. Methods: Chitosan-coated PLGA nanoparticles (PLGA-C NPs) encapsulating OSI were prepared using a single emulsion-solvent evaporation technique. PLGA-C NPs were assembled into respirable nanocomposite microparticles (NCMPs) via spray drying with L-leucine as a carrier. PLGA-C NPs were characterized for particle size, zeta-potential, encapsulation efficiency, and in vitro efficacy in A-549 cell line. NCMPs were evaluated for solid-state properties, aerosolization performance, stability and in vitro release. Results: PLGA-C NPs exhibited a particle size of 145.18 ± 3.0 nm, high encapsulation efficiency and a positive zeta potential. In vitro studies demonstrated a 3.6-fold reduction in IC50 compared to free OSI, superior antimigratory effects and enhanced cell cycle arrest. Solid-state characterization of NCMPs demonstrated drug encapsulation in the polymer without chemical interaction. NCMPs exhibited excellent aerosolization (mass median aerodynamic diameter of 1.09 ± 0.23 μm, fine particle fraction of 73.48 ± 8.6%) and sustained drug release (61.76 ± 3.9% at 24 h). Stability studies confirmed the physicochemical stability integrity. Conclusions: These findings suggest that this novel dry powder inhalable OSI formulation may improve therapeutic outcomes while reducing systemic toxicity. Full article
(This article belongs to the Special Issue Anticancer Nanotherapeutics for Lung Cancer Therapy)
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