Dispersed System for Controlled Drug Release and Delivery—the Path to Effective Therapeutic Solutions

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 1200

Special Issue Editors


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Guest Editor

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Guest Editor
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warynskiego 1, 00-645 Warsaw, Poland
Interests: drug delivery systems; controlled drug release; multiple emulsions

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to innovative strategies for precise, targeted and controlled drug release and delivery, focusing on the progress in drug delivery associated with the use of nano- and microscale dispersed systems.

In this area, dispersed systems play a pivotal role, mainly due to their ability to finely modulate the release of active substances. This is attributed to their capacity to precisely control the release kinetics, making dispersed systems such as micro-/nanoemulsions, multiple emulsions, liposomes and nanosuspensions essential tools for enhancing the effectiveness of drug delivery.

Moreover, dispersed system-based advanced formulations enable the development of pharmaceutical forms that improve the bioavailability of active substances and minimize potential side effects. Consequently, dispersed systems in controlled-release formulations emerge as central contributors to progress in drug delivery, positively impacting therapeutic efficacy and patient comfort.

Dr. Maria Camilla Bergonzi
Dr. Agnieszka Markowska-Radomska
Guest Editors

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Keywords

  • drug delivery systems
  • controlled drug release
  • dispersed systems
  • microemulsions
  • nanoemulsions
  • multiple emulsions
  • liposomes
  • nanosuspensions
  • self-emulsifying drug delivery system (SEDDS)
  • colloids
  • micelles

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Published Papers (1 paper)

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Review

47 pages, 2480 KiB  
Review
Advances in the Functionalization of Vaccine Delivery Systems: Innovative Strategies and Translational Perspectives
by Ingrid Andrêssa de Moura, Anna Jéssica Duarte Silva, Larissa Silva de Macêdo, Karina Mayumi Tani Bezerra de Melo, Lígia Rosa Sales Leal, Benigno Cristofer Flores Espinoza, Maria da Conceição Viana Invenção, Samara Sousa de Pinho and Antonio Carlos de Freitas
Pharmaceutics 2025, 17(5), 640; https://doi.org/10.3390/pharmaceutics17050640 - 12 May 2025
Viewed by 452
Abstract
The development of effective vaccines requires a rational design that considers the interaction between antigens, their vectors, and the immune system in addition to the activation of pathways that induce a safe and specific immune response. The efficacy of a vaccine formulation depends [...] Read more.
The development of effective vaccines requires a rational design that considers the interaction between antigens, their vectors, and the immune system in addition to the activation of pathways that induce a safe and specific immune response. The efficacy of a vaccine formulation depends on the nature of the antigen, the protection offered by the delivery system, the ability to potentiate the immune response, and the precise release of the immunogen. Carrier systems such as lipid nanoparticles, polymers, exosomes, and microorganisms can be functionalized by chemical, physical, or biological methods to generate selective and improved biodistribution profiles. These methods enhance interaction with target cells, thereby improving immunological efficacy. The conjugation of specific ligands or the modification of parameters such as shape, charge, and size of vectors can enhance the specificity, stability, and efficiency of antigen transport to cellular compartments, thereby facilitating a robust immune response. This study examines modifications in vaccine delivery systems, focusing on biomolecules and physicochemical changes that enhance antigen presentation. Additionally, we examine innovative methods, including microneedles, electroporation, and needle-free systems that show potential for enhancing the immune response. Full article
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