Microfluidics-Driven Formulations: Exploring Liposomes and Emulsions for Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 848

Special Issue Editors


E-Mail Website
Guest Editor
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Interests: microfluidics; liposomes; emulsions technology; biophysics; synthetic cells

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the transformative potential of microfluidics in drug delivery systems, emphasizing the development of liposomes and emulsions as versatile platforms. Microfluidics offers unparalleled control over designing innovative drug delivery systems while enabling precise size and compositional control. By integrating advanced materials and scalable fabrication techniques, microfluidics is paving the way for personalized medicine and the next generation of targeted therapies.

This Special Issue seeks contributions that delve into microfluidic technologies, spanning from design to production while tackling the challenges of developing robust formulations. Research focused on the application-specific design of liposomes and emulsion-based micro- and nano-carriers, presenting innovations in drug delivery, is particularly welcome. Submissions highlighting engineering advancements in simulation-driven optimization and device designs for scalable, high-throughput production are also encouraged.

Join us in showcasing the latest breakthroughs at the intersection of microfluidics, material science, and pharmaceutical innovations, paving the way for the next-generation of drug delivery solutions.

Dr. Naresh Yandrapalli
Prof. Dr. Maria Camilla Bergonzi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microfluidics
  • drug delivery systems
  • liposomes
  • emulsions
  • synthetic cells
  • personalized medicine
  • multi-drug therapy
  • scalable manufacturing
  • micro-/nano-carriers
  • material science
  • pharmaceutical innovation
  • engineering solutions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

23 pages, 2805 KB  
Article
Microfluidic Design of Ultradeformable Liposomes for Advanced Skin Delivery of Stellaria media Phytocomplex
by Luigi Ciriolo, Nicola d’Avanzo, Antonia Mancuso, Maria Chiara Cristiano, Antonella Barone, Rosario Mare, Anna Maria Tolomeo, Alexandra I. Comaniciu, Georgiana Nitulescu, Octavian Tudorel Olaru, Felisa Cilurzo, Donatella Paolino and Massimo Fresta
Pharmaceutics 2025, 17(11), 1390; https://doi.org/10.3390/pharmaceutics17111390 - 27 Oct 2025
Viewed by 567
Abstract
Background/Objectives: Ultradeformable liposomes represent an established platform for topical delivery of antioxidant compounds, thanks to their structural flexibility and ability to enhance skin permeation, but standardized manufacturing protocols are still lacking. This study presents a microfluidic-based strategy for the scalable production of ultradeformable [...] Read more.
Background/Objectives: Ultradeformable liposomes represent an established platform for topical delivery of antioxidant compounds, thanks to their structural flexibility and ability to enhance skin permeation, but standardized manufacturing protocols are still lacking. This study presents a microfluidic-based strategy for the scalable production of ultradeformable liposomes encapsulating Stellaria media extract, a polyphenol-rich phytocomplex with strong antioxidant activity. Methods: Liposomes were produced with a GMP-like microfluidic platform enabling fine control of formulation parameters and high reproducibility under conditions directly transferable to continuous manufacturing. Process optimization tested different total flow rates. Characterization included particle size and distribution, encapsulation efficiency, colloidal stability and kinetics of release. Permeation was assessed with Franz diffusion cells using human stratum corneum and epidermidis membranes. Results: Optimal conditions were a flow rate ratio of 3:1 and a total flow rate of 7 mL/min, yielding ultradeformable liposomes with a mean size of 89 ± 1 nm, a polydispersity index < 0.25, and high encapsulation efficiency (72%). The resulting formulation showed long-term colloidal stability and controlled release. Diffusion studies demonstrated a 2-fold increase in permeation rate compared to the free extract. Conclusions: These findings highlight the potential of microfluidics as a robust and scalable technology for the industrial production of ultradeformable liposomes designed to enhance the dermal delivery of bioactive phytocomplex for both pharmaceutical and cosmeceutical applications. Full article
Show Figures

Graphical abstract

Back to TopTop