Co-and Post-translational Modifications of Therapeutic Proteins
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 12117
Special Issue Editors
Interests: PTM; Structural bioinformatics; protein-structural-dynamics-function; drug design
Special Issue Information
Post-translational modifications (PTMs) add a layer of complexity to the proteome through the addition of biochemical moieties to specific residues of proteins, with low evolutionary cost. With the rapid development of high-throughput mass spectrum in the discovery of PTM sites, functional studies have become the bottleneck in the coming era of functional omics. PTMs could alter protein associations, protein structural conformations, and cellular localizations, involved in various of biological processes and disease pathogenesis. With the deciphering of PTM functional landscape, PTMs can play crucial roles as biomarkers in precision medicine. On the other hand, concerning the limited biological space in drug design, the introduction of PTM functional groups would extremely enlarge the target space for drug design with high selectivity. In the research of PTM function, two layers would be considered. First is the molecular level, where, with the introduction of PTMs, the structural and dynamics effects on proteins should be considered. Second, PTMs act as the connector of protein–protein interactions, which could provide us with a systematic view for PTM functions. In our PTM issue, we shall focus on functional research for PTM sites and protein structural isoforms with PTMs, both computationally and experimentally, including but not limited to:
- Biological functions of protein with PTMs (experimental studies and computational studies);
- Structure–dynamics–function relationship of PTM structural isoforms;
- Machine learning models for the prediction of PTM functions;
- Machine learning models for the prediction of crosstalk of PTM pairs;
- Research on PTM intermediated PPI networks in specific disease;
- Chemical-biology-related studies of PTMs;
- Drug discovery targeting PTMs and PTM structural isoforms.
Dr. Zhongjie Liang
Dr. Fanwang Meng
Guest Editors
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Keywords
- PTM function
- PTM isoform
- machine learning
- PTM intermediated PPI network
- drug design
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