Advances in Antiparasitic Natural Products

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (20 November 2024) | Viewed by 1812

Special Issue Editor


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Guest Editor
Laboratório de Pesquisa em Parasitologia, Av. Dr. Armando Salles de Oliveria, Franca 14404-600, SP, Brazil
Interests: neglected tropical disease; drug discovery; natural products; proteasome

Special Issue Information

Dear Colleagues,

Parasitic diseases concern health and human life, particularly infections caused by protozoans and helminths, such as malaria, trypanosomiasis, leishmaniasis, Chagas disease, schistosomiasis, onchocerciasis, lymphatic filariasis, and helminthiases. On a global scale, parasitic diseases are responsible for almost one million deaths yearly. In recent years, parasites have been exhibiting resistance to known conventional treatments, which are costly and out of reach for many impoverished individuals. The exploration of potential botanical antiparasitics, which are inexpensive and abundant, may be a promising alternative in this context.

This special issue will focus on natural products with antiparasitic activity. We invite scholars to submit original research articles or review articles.

Dr. Lizandra Guidi Magalhães
Guest Editor

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Keywords

  • parasites
  • antiparasitics
  • natural products

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Published Papers (1 paper)

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Research

11 pages, 6943 KiB  
Article
Efficacy of Diterpene Polyalthic Acid Combined with Amphotericin B against Leishmania amazonensis In Vitro
by Ana Carolina Bolela Bovo Candido, Mariana Cintra Pagotti, Daiane Albino dos Santos, Lucas Antonio de Lima Paula, Rodrigo Cássio Sola Veneziani, Jairo Kenupp Bastos, Sérgio Ricardo Ambrósio and Lizandra Guidi Magalhães
Pharmaceuticals 2024, 17(9), 1243; https://doi.org/10.3390/ph17091243 - 21 Sep 2024
Cited by 3 | Viewed by 1159
Abstract
Background/Objectives: Leishmaniasis, a neglected disease caused by Leishmania spp. including L. amazonensis, urgently requires new treatments. Polyalthic acid (PA), a natural diterpene from Copaifera spp., has previously demonstrated significant antiparasitic potential. This study evaluated the leishmanicidal effects of polyalthic acid (PA), alone [...] Read more.
Background/Objectives: Leishmaniasis, a neglected disease caused by Leishmania spp. including L. amazonensis, urgently requires new treatments. Polyalthic acid (PA), a natural diterpene from Copaifera spp., has previously demonstrated significant antiparasitic potential. This study evaluated the leishmanicidal effects of polyalthic acid (PA), alone and with amphotericin B (AmpB), on L. amazonensis promastigote and amastigote forms. Results: PA showed significant activity against promastigotes, with 50% effective concentration (EC50) values of 2.01 μM at 24 h and an EC50 of 3.22 μM against amastigotes after 48 h. The PA and AmpB combination exhibited a synergistic effect on both forms without inducing cytotoxicity or hemolysis. Morphological changes in promastigotes, including vacuole formation and cell rounding, were more pronounced with the combination. Conclusions: These findings suggest that PA and AmpB together could form a promising new treatment strategy against Leishmania infections, offering enhanced efficacy without added toxicity. Full article
(This article belongs to the Special Issue Advances in Antiparasitic Natural Products)
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