Supersaturated Formulations in Drug Development: From Solubility Investigations to the Advancement of In Vitro–In Vivo Predictability

Dear Colleagues, 

Formulation development has become an increasingly prominent area in pharmaceutical research, driven by the need to improve the bioavailability of drugs with poor aqueous solubility. One promising way to achieve this is through systems that can generate supersaturated solutions, increasing the amount of drug available for absorption and improving therapeutic outcomes.

A common feature of such formulations is that the active ingredient is present in a non-equilibrium, supersaturated state, which can be achieved through approaches such as amorphous dispersions, nanosized systems, or other technologies. These concepts are closely related to kinetic and amorphous solubility, as well as the phenomena of liquid–liquid phase separation, precipitation, and recrystallization. As more of these formulations enter research and development, there is a growing demand for deeper knowledge of their behavior and for reliable methods to measure and interpret solubility-related data in ways that can guide both formulation design and in vivo prediction.

This Special Issue invites contributions that address supersaturation and dissolution behavior in advanced drug formulations. Relevant topics include experimental and analytical methods for determining solubility limits, evaluation of kinetic and amorphous states, studies on phase transitions, mechanistic insights into supersaturation maintenance, and in vitro or in silico approaches to anticipate absorption. Works that combine solubility characteristics with formulation development or predictive modeling may be particularly valuable.

The purpose of this Special Issue is to provide deeper insight into how dissolution mechanisms influence the performance of drug formulations, supporting the development of more effective medicines.

Dr. Réka Angi
Dr. Tamas Solymosi
Dr. Anna Vincze
Prof. Dr. María Peña Fernández
Dr. Ziyaur Rahman
Guest Editors

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