Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.1
4.3
Journals
Pharmaceuticals
Special Issues
Drug Insights: Vitamin D and Its Analogs 2023
share announcement

Drug Insights: Vitamin D and Its Analogs 2023

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (10 April 2024) | Viewed by 4037

Special Issue Editor

Prof. Julia O. Fedotova

E-Mail Website
Guest Editor
1. Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Emb. Makarova, 199034 St. Petersburg, Russia
2. International Research Centre "Biotechnologies of the Third Millennium", ITMO University, 9 Lomonosova Str., 191002 St. Petersburg, Russia
Interests: brain; behavior; anxiety; depression; memory; learning; schizophrenia; nutrients; nutraceuticals; vitamin D; estrogens; progesterone; DHEA; menopause; thyroid hormones; androgens; fertility; pharmacotherapy; psychology; psychoneuropharmacology; nutraceutical psychiatry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues, 

Vitamin D is an exciting topic in scientific research, especially in the last few decades. It is one of the first hormones, or even the very first one, produced on Earth. Many preclinical and clinical studies have strongly indicated that vitamin D plays several physiological and biochemical key roles in different areas of general physiology and pathophysiology. However, many questions still remain and will likely fuel ongoing investigations and debate. It is also likely that these questions will increase researchers’ interest in the different pleiotropic effects of vitamin D in the future.

This Special issue will provide a scientific perspective on vitamin D and its analogs in the mechanisms of endocrine disorders associated with gonadal hormone imbalance in men and women. This Special Issue will include both experimental/clinical articles and reviews concentrated on the most recent advances in the research into Vitamin D and its analogs used in the treatment of gonadal hormonal disorders. The major focus will be on the pleotropic action of vitamin D on the gonadal axis in both genders, with a special focus on the molecular and biochemical mechanisms of vitamin D involvement, and studies on the treatment with vitamin D and its analogs in the complex therapy of sexual hormonal disorders.

Prof. Julia O. Fedotova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamin D
  • estrogens
  • progesterone
  • DHEA
  • menopause
  • androgens
  • fertility
  • pharmacotherapy
  • psychology

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

24 pages, 3016 KiB  
Article
Safety and Efficacy of Loading Doses of Vitamin D: Recommendations for Effective Repletion
by Béla E. Tóth, István Takács, Kristóf Kádár, Sara Mirani, Miklós Vecsernyés and Péter Lakatos
Pharmaceuticals 2024, 17(12), 1620; https://doi.org/10.3390/ph17121620 - 30 Nov 2024
Cited by 1 | Viewed by 3585
Abstract
Background/Objectives: Epidemiological data on vitamin D status revealed that, despite various dosage and durations of supplementation, the effectiveness often fails to achieve optimal outcomes. The need for higher doses than previously recommended was suggested, but several modifying factors should be considered, including the [...] Read more.
Background/Objectives: Epidemiological data on vitamin D status revealed that, despite various dosage and durations of supplementation, the effectiveness often fails to achieve optimal outcomes. The need for higher doses than previously recommended was suggested, but several modifying factors should be considered, including the level of deficiency, and BMI. The objectives of this post hoc evaluation are to characterize treatment effectiveness based on the applied dose, duration and BMI; and to assess the safety aspects associated with rapid repletion of vitamin D. Methods: Vitamin D deficient subjects selected in the post-hoc analysis: seventy patients included from a combined loading-maintenance supplementation (300,000 IU followed by 60,000 IU) protocol and 62 deficient subjects who received a low-dose maintenance (1000 IU/day) therapy. The risk of overload and the incidence of hypercalciuria and hypercalcemia resulting from loading or post-loading maintenance were investigated. Results: The moderate–fast-loading schedule of 60,000 IU per week for 5 weeks, effectively achieves the target in 25(OH)D levels over 30 ng/mL for all deficient subjects, regardless of their BMI. Slower loading with lower weekly doses confirms the safety of supplementation, but the effectiveness is dependent on the subjects’ BMI; overweight and obese patients require higher doses to reach the same vitamin D levels. No difference in safety parameters observed compared to low-dose therapies. Conclusions: The loading treatment involving a total dose of 300,000 IU administered over 5 or 10 weeks is effective for repletion, does not lead to 25(OH)D overload, and poses no additional risks of hypercalcemia or hypercalciuria. Furthermore, there are no safety concerns regarding changes in bone resorption markers. A combination of the loading treatment with a subsequent maintenance dose of 2000 IU daily is adequate to achieve the target vitamin D levels. Full article
(This article belongs to the Special Issue Drug Insights: Vitamin D and Its Analogs 2023)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop