Dear Colleagues,

The contribution of medicine in overcoming human diseases is great and, as a result, human health and lifespan have been greatly increased. Drugs for the treatment of various diseases are continuously being developed, and formulation research is progressing at a remarkable speed. However, in the reality that most medicines rely on empirical usage and apply uniformly to all people, preparing effective alternatives and ways to overcome this has become a very important concern. Precision medicine and individualized drug therapy are very important research areas, as important as drug development for effective clinical application through reductions in side effects and maximization of drug efficacy.

This Special Issue focuses on the application and current status of pharmacometric studies for the realization and advancement of precision medicine. Therefore, pharmacokinetics, pharmacodynamics, in vivo drug quantification, and genetic polymorphism studies (such as enzymes or transporters involved in drug absorption, distribution, metabolism, and excretion) for precision medicine and individualized pharmacotherapy settings will be suitable for this Special Issue scope. In addition, studies on predicting drug behavior and efficacy in the body through mathematical modeling, exploring clinical usage based on models, and exploring effective covariates to explain the diversity of pharmacokinetics and pharmacodynamics among individuals will be very welcome. Finally, it is expected that a lot of useful and interesting research information for the realization of precision medicine will be introduced in this Special Issue.

Dr. Seung-Hyun Jeong
Prof. Dr. Yong-Bok Lee
Guest Editors

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• precision medicine
• individualized therapy
• pharmacometrics
• mathematical modeling
• quantitative prediction
• regimen setting
• drug-response variability