Special Issue "Salmonella Persistent Infections"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: 20 September 2021.
The gram-negative bacilli Salmonella affect many millions annually worldwide and cause salmonellosis including the life-threatening disease typhoid fever. Currently, the treatment for Salmonella infections relies largely on vaccination and antibiotics. However, recent epidemiology studies have revealed the worrisome trend that multidrug-resistant and extensively drug-resistant strains of Salmonella are rapidly spreading. The best knowledge of the molecular mechanisms of this important bacterial pathogen will facilitate disease prevention, surveillance and control, and improve diagnostics and may help to facilitate the development of more efficacious vaccines and new therapeutics alternative to antibiotics. Among the dynamic, complex lifecycle of Salmonella, its persistent infection and transmission is one of the least understood areas in the field, although we need to interrupt this stage of infections to effectively tackle salmonellosis. For this Special Issue of Pathogens, we invite you to submit a review or research article related to molecular aspects of Salmonella persistent infections. We look forward to your contribution.
Dr. Jeongmin Song
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Host-microbe interactions
- Interactions with other microbes, both beneficial and pathogenic
- Effects of various health conditions
- Colonization and immune evasion
- Persistent infection
- Immune responses
- Antibiotic resistance
- Current treatment
- Prevention and control
- Molecular tools and approaches
- Animal models
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: Control of persistent Salmonella infection relies on constant thymic output despite increased peripheral antigen-specific T cell immunity
Authors: James B. McLachlan
Affiliation: Tulane University School of Medicine Department of Microbiology and Immunology
Abstract: Recent thymic emigrants are the youngest subset of peripheral T cells but their involvement in combating persistent bacterial infections has not been explored. Here, we hypothesized that CD4+ recent thymic emigrants are essential immune mediators during persistent Salmonella infection. To test this, we thymectomized adult mice either prior to, or during, persistent Salmonella infection. We found that thymic output is crucial in the formation of protective immune responses during the early formation of a Salmonella infection but is dispensable once chronic Salmonella infection is established. Further, we show that thymectomized mice demonstrate increased infection-associated mortality and bacterial burdens. Unexpectedly, numbers of Salmonella-specific CD4+ T cells were significantly increased in thymectomized mice compared to sham control mice. Lastly, we found that T cells from thymectomized mice may be impaired in producing the effector cytokine IL-17 at early time points of infection, compared to thymically intact mice. Together, these results imply a unique role for thymic output in the formation of immune responses against a persistent, enteric pathogen.