Topical Collection "Vitamin D in the New Decade: Facts, Controversies, and Future Perspectives for Daily Clinical Practice"

A topical collection in Nutrients (ISSN 2072-6643). This collection belongs to the section "Micronutrients and Human Health".


Dr. Spyridon N. Karras
E-Mail Website
Collection Editor
Division of Endocrinology and Metabolism, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA Hospital, 55535 Thessaloniki, Greece
Interests: intermittent fasting; periodic fasting; religious fasting: fasting glucose; obesity; impaired fasting glucose; non-fasting triglycerides; fasting blood glucose; caloric restriction; meal frequency; calorie restriction
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Topical Collection Information

Dear Colleagues,

Vitamin D has been the focus of ongoing scientific research over the past two decades. Its undisputed primogenetic role in bone mineralization has been expanded to a strikingly disparate amalgamation of transparent scientific cases and observational studies, randomized controlled trials of dubious design, and sporadically personal aphorisms and dogma. This phenomenon configures a burgeoning scientific field in which substantial controversy is inevitably reflected in daily clinical practice, resulting in a precarious interpretation of not necessarily available results, lifestyle-affected vitamin D supplementation in vitamin D sufficient populations, and ineffective dosing and time regimens.

In this context, somewhere in between the dipole of inordinate enthusiasm and critical opposition, the vast majority of healthcare providers worldwide, who are involved in some part of the developed vitamin D agenda, postulate a sound individualized scientific approach unbiased from quandaries and oriented to improve long-term health outcomes and patient quality of life—beyond the Platonic caves of available knowledge in the field.

This Collection will draw attention to all the intriguing and conflicting aspects of vitamin D research, including the following: Vitamin D deficiency and its widespread epidemiology; musculoskeletal and extra-skeletal effects; and critical updates on published vitamin D supplementation prevention RCTs (cancer/ CVD). It will also include discourse on the future agenda with the main questions: What has changed so far in the field? What are future research milestones? In collecting the results reported here, the editors have not endeavored to achieve any sort of completeness, but rather to shed light on the ongoing controversy of the vitamin D “friendly” perspective versus vitamin D skepticism, with a discourse on clinical implications and physicians’ daily decision making into the beginning of the new decade.

Dr. Spyridon N. Karras
Collection Editor

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  • vitamin D
  • nutrition
  • infections
  • epidemiology
  • cardiovascular disease

Published Papers (1 paper)


Maternal and Neonatal Vitamin D Binding Protein Polymorphisms and 25-Hydroxyvitamin D Cutoffs as Determinants of Neonatal Birth Anthropometry
Nutrients 2022, 14(18), 3799; - 15 Sep 2022
Viewed by 295
Background: Vitamin D-binding protein (VDBP) is a vital regulator of optimal vitamin D homeostasis and bioavailability. Apart from its well-documented role as a key component in vitamin D dynamic transfer and circulation, it has a myriad of immunoregulatory functions related to innate immunity, [...] Read more.
Background: Vitamin D-binding protein (VDBP) is a vital regulator of optimal vitamin D homeostasis and bioavailability. Apart from its well-documented role as a key component in vitamin D dynamic transfer and circulation, it has a myriad of immunoregulatory functions related to innate immunity, which becomes particularly critical in states of increased immunological tolerance including pregnancy. In this regard, VDBP dyshomeostasis is considered to contribute to the development of several fetal, maternal, and neonatal adverse outcomes. However, precise physiological pathways, including the contribution of specific VDBP polymorphisms behind such phenomena, are yet to be fully deciphered. Our aim was to assess the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on the neonatal anthropometric profile at birth. Methods: The study included data and samples from a cohort of 66 mother–child pairs at birth. The inclusion criterion was full-term pregnancy (gestational weeks 37–42). Neonatal and maternal 25(OH)D cutoffs were included according to vitamin D status at birth and delivery. Concentrations of 25(OH)D2 and 25(OH)D3 were measured using liquid chromatography–tandem mass spectrometry. Results: The upper arm length of neonates with 25(OH)D ≤ 25 nmol/L was higher in neonate CC carriers for rs2298850. The upper thigh neonatal circumference was also higher in the ones with either 25(OH)D ≤ 50 or ≤75 nmol/L in rs2298850 CG + GG or rs4588 GT + TT carriers. We did not observe any significant effect for maternal VDBP polymorphisms nor for birth maternal 25(OH)D concentrations, on birth neonatal anthropometry. Conclusions: Our findings emphasize a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in the range of sufficiency on neonatal growth and development. Full article
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