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Article

Maternal and Neonatal Vitamin D Binding Protein Polymorphisms and 25-Hydroxyvitamin D Cutoffs as Determinants of Neonatal Birth Anthropometry

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Laboratory of Biological Chemistry, Medical School, Aristotle University, 55535 Thessaloniki, Greece
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Brain and Neurodegenerative Disorders Research Laboratories, Department of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, 34320 Istanbul, Turkey
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Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria
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Department of Geriatric Medicine and Memory Clinic, Research Centre on Autonomy and Longevity, University Hospital, 49933 Angers, France
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Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON N6A 3K7, Canada
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Department of Health Sciences, College of Natural and Health Sciences, Zayed University, Abu Dhabi P.O. Box 144534, United Arab Emirates
*
Author to whom correspondence should be addressed.
Academic Editor: Alexandre Lapillonne
Nutrients 2022, 14(18), 3799; https://doi.org/10.3390/nu14183799
Received: 26 August 2022 / Revised: 9 September 2022 / Accepted: 9 September 2022 / Published: 15 September 2022
Background: Vitamin D-binding protein (VDBP) is a vital regulator of optimal vitamin D homeostasis and bioavailability. Apart from its well-documented role as a key component in vitamin D dynamic transfer and circulation, it has a myriad of immunoregulatory functions related to innate immunity, which becomes particularly critical in states of increased immunological tolerance including pregnancy. In this regard, VDBP dyshomeostasis is considered to contribute to the development of several fetal, maternal, and neonatal adverse outcomes. However, precise physiological pathways, including the contribution of specific VDBP polymorphisms behind such phenomena, are yet to be fully deciphered. Our aim was to assess the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on the neonatal anthropometric profile at birth. Methods: The study included data and samples from a cohort of 66 mother–child pairs at birth. The inclusion criterion was full-term pregnancy (gestational weeks 37–42). Neonatal and maternal 25(OH)D cutoffs were included according to vitamin D status at birth and delivery. Concentrations of 25(OH)D2 and 25(OH)D3 were measured using liquid chromatography–tandem mass spectrometry. Results: The upper arm length of neonates with 25(OH)D ≤ 25 nmol/L was higher in neonate CC carriers for rs2298850. The upper thigh neonatal circumference was also higher in the ones with either 25(OH)D ≤ 50 or ≤75 nmol/L in rs2298850 CG + GG or rs4588 GT + TT carriers. We did not observe any significant effect for maternal VDBP polymorphisms nor for birth maternal 25(OH)D concentrations, on birth neonatal anthropometry. Conclusions: Our findings emphasize a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in the range of sufficiency on neonatal growth and development. View Full-Text
Keywords: vitamin D; pregnancy; polymorphism; birth anthropometry vitamin D; pregnancy; polymorphism; birth anthropometry
MDPI and ACS Style

Karras, S.N.; Dursun, E.; Alaylıoğlu, M.; Gezen-Ak, D.; Pilz, S.; Annweiler, C.; Al Anouti, F. Maternal and Neonatal Vitamin D Binding Protein Polymorphisms and 25-Hydroxyvitamin D Cutoffs as Determinants of Neonatal Birth Anthropometry. Nutrients 2022, 14, 3799. https://doi.org/10.3390/nu14183799

AMA Style

Karras SN, Dursun E, Alaylıoğlu M, Gezen-Ak D, Pilz S, Annweiler C, Al Anouti F. Maternal and Neonatal Vitamin D Binding Protein Polymorphisms and 25-Hydroxyvitamin D Cutoffs as Determinants of Neonatal Birth Anthropometry. Nutrients. 2022; 14(18):3799. https://doi.org/10.3390/nu14183799

Chicago/Turabian Style

Karras, Spyridon N., Erdinç Dursun, Merve Alaylıoğlu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, and Fatme Al Anouti. 2022. "Maternal and Neonatal Vitamin D Binding Protein Polymorphisms and 25-Hydroxyvitamin D Cutoffs as Determinants of Neonatal Birth Anthropometry" Nutrients 14, no. 18: 3799. https://doi.org/10.3390/nu14183799

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