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Health Benefits of Plant Sterols

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (10 September 2020) | Viewed by 6114

Special Issue Editor


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Guest Editor
1. Department of Psychiatry & Neuropsychology, School for Mental Health and Neuroscience—Division Translational Neuroscience, Maastricht University, Maastricht, The Netherlands
2. NIC&R—Neuro-Immune Connect & Repair, BIOMED—Faculty of Medicine and Life Sciences, Hasselt University, Hasselt, Belgium
Interests: plant sterols; central nervous system; inflammation; cholesterol; cognition; multiple sclerosis; Alzheimer’s disease; repair

Special Issue Information

Dear Colleagues,

Current evidence indicates that food matrices with added plant sterols or stanols can lower serum levels of low-density lipoprotein cholesterol. Interestingly, plant sterols and plant stanols show health benefits beyond the cholesterol lowering effect, such as modulation of inflammation and cognitive processes. Nutritional plant sterols and plant stanols are mainly linked to processes in health but are exceptionally also linked to disease. Currently, plant sterols and plant stanols are applied as food-additives to the diet and as add-on treatment to drugs. Interestingly, different classes of responders to plant sterol-enriched diets are encountered. To cope with the responder effect, personalized treatment regimens are gaining attention. To reproducibly detect plant sterols and plant stanols and their metabolites in biological tissues, methodological challenges are encountered in reliably quantifying these sterols. Consequently, novel technical advances are explored to achieve reproducible interlaboratory quantification protocols. Although plant sterols and stanols continue to offer an efficacious and convenient dietary approach to cholesterol management, long-term clinical trials investigating the endpoints of cardiovascular disease are still lacking.

Dr. Tim Vanmierlo
Guest Editor

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Keywords

  • Plant sterol
  • Plant stanol
  • Phytosterol
  • Cholesterol
  • Lipoprotein
  • Inflammation
  • Health
  • Disease
  • Nutrition

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Published Papers (1 paper)

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12 pages, 639 KiB  
Discussion
Lowering Low-Density Lipoprotein Cholesterol Concentration with Plant Stanol Esters to Reduce the Risk of Atherosclerotic Cardiovascular Disease Events at a Population Level: A Critical Discussion
by Helena Gylling, Timo E. Strandberg, Petri T. Kovanen and Piia Simonen
Nutrients 2020, 12(8), 2346; https://doi.org/10.3390/nu12082346 - 6 Aug 2020
Cited by 11 | Viewed by 5456
Abstract
Atherosclerotic cardiovascular diseases (ASCVDs) cause every fifth death worldwide. However, it is possible to prevent the progression of ASCVDs by reducing circulating concentrations of low-density lipoprotein cholesterol (LDL-C). Recent large meta-analyses demonstrated that by reducing the dietary intake of saturated fat and cholesterol, [...] Read more.
Atherosclerotic cardiovascular diseases (ASCVDs) cause every fifth death worldwide. However, it is possible to prevent the progression of ASCVDs by reducing circulating concentrations of low-density lipoprotein cholesterol (LDL-C). Recent large meta-analyses demonstrated that by reducing the dietary intake of saturated fat and cholesterol, it is possible to reduce the risk of ASCVD events. Plant stanols, as fatty-acid esters, were developed as a dietary adjunct to reduce LDL-C levels as part of a heart-healthy diet. They reduce cholesterol absorption so that less cholesterol is transported to the liver, and the expression of LDL receptors is upregulated. Ultimately, LDL-C concentrations are reduced on average by 9–12% by consuming 2–3 g of plant stanol esters per day. In this review, we discuss recent information regarding the prevention of ASCVDs with a focus on dietary means. We also present new estimates on the effect of plant stanol ester consumption on LDL-C levels and the risk of ASCVD events. Plant stanol esters as part of a heart-healthy diet plausibly offer a means to reduce the risk of ASCVD events at a population level. This approach is not only appropriate for subjects with a high risk of ASCVD, but also for subjects at an apparently lower risk to prevent subclinical atherosclerosis. Full article
(This article belongs to the Special Issue Health Benefits of Plant Sterols)
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