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The Impact of Dietary Nutrients and Dietary Habits on Alzheimer’s Disease and Dementia

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Geriatric Nutrition".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 1078

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Department of Life Science, Health and Health Professions, Link Campus University, 00165 Rome, Italy
Interests: neurodegeneration; inflammation; mitochondria; oxidative stress
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Special Issue Information

Dear Colleagues,

The life expectancy is increasing worldwide, and the global population is growing, resulting in an enhanced increment of elderly individuals and age-related diseases. Dementia is a severe impairment of the cognitive function that affects daily life and represents a huge problem for the health and economic system. Alzheimer’s disease (AD) is the major disease leading to dementia. Dementia and AD are promoted by genetic predisposition, aging, environmental factors, nutrition, and lifestyle habits. In particular, there is no cure for AD. Thus, it is important to investigate the role of risk factors in order to prevent AD. Several data demonstrate that dietary habits play an important role in preventing the onset and progression of dementia and AD. Supplementation with dietary nutrients seems to be beneficial against dementia and AD. Nutrients and dietary habits exert an essential role on the microbiota composition, modulating the gut–brain axis and, in turn, the onset and progression of dementia and AD.

This Special Issue aims to collect research articles and review articles providing recent advances in the study of the role of nutrients and dietary habits on dementia, AD, and on the role of the microbiota–gut–brain axis in cognitive function.

Dr. Lorena Perrone
Guest Editor

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Keywords

  • dementia
  • Alzheimer’s disease
  • nutrients
  • diet
  • dietary habits
  • microbiota
  • gut–brain axis
  • microbiota–gut–brain axis
  • metabolism

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Published Papers (1 paper)

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Research

16 pages, 1460 KB  
Article
Association Between cMIND Diet and Dementia Among Chinese Older Adults: A Population-Based Cross-Sectional Study
by Yu Zhang, Yuanyuan Lan, Youtao Mou, Yingjiao Deng, Ziyi Chen, Yandi Fu, Zumin Shi, Lei Zhang and Yong Zhao
Nutrients 2025, 17(22), 3529; https://doi.org/10.3390/nu17223529 - 11 Nov 2025
Viewed by 552
Abstract
Background: China’s rapidly aging population has led to a growing burden of dementia, marked by cognitive decline and heavy social and economic costs. Dietary patterns have been identified as a critical means for prevention. Methods: This study drew on data from the China [...] Read more.
Background: China’s rapidly aging population has led to a growing burden of dementia, marked by cognitive decline and heavy social and economic costs. Dietary patterns have been identified as a critical means for prevention. Methods: This study drew on data from the China Longitudinal Health and Longevity Survey (CLHLS). Three logistic regression models were applied to examine the association between the Chinese version of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (cMIND) diet and dementia. To test the stability of the results, we conducted two sensitivity analyses. Restricted cubic spline (RCS) models were used to assess the potential for a nonlinear relationship. Subgroup and interaction analyses were conducted to explore heterogeneity across covariates and main effects. Propensity score matching (PSM) was performed as a secondary analysis to minimize the influence of confounding factors. Results: The study included 9142 participants, with a dementia prevalence of 10.7% among Chinese older adults. After adjusting for all covariates, each one-unit increase in the cMIND diet score was associated with an 11% lower prevalence of dementia (OR = 0.89; 95% CI: 0.84–0.93). After full adjustment, the RCS model confirmed a significant and linear dose–response association between adherence to the cMIND diet and dementia. Comparable associations were observed across most subgroups. Conclusions: Adherence to the cMIND diet was significantly associated with a lower prevalence of dementia in Chinese older adults, with evidence of a clear dose–response effect. These findings highlight the potential of the cMIND diet as a preventive strategy against dementia in this population. Full article
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