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Diet, Nutrition and Body Tissues in Patients with Heart Failure

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutritional Epidemiology".

Deadline for manuscript submissions: 5 December 2026 | Viewed by 896

Special Issue Editors


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Guest Editor
Department of Internal Medicine, General Hospital Murska Sobota, Ulica dr. Vrbnjaka 6, SI-9000 Murska Sobota, Slovenia
Interests: heart failure; COPD; iron deficiency; cachexia; sarcopenia; frailty; cardiovascular disease
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Guest Editor
Department of Cardiology & Pneumology, Universitätsmedizin Göttingen, D-37099 Göttingen, Germany
Interests: heart failure; comorbidities; biomarkers; pharmacotherapy; exercise capacity; quality of life
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Cardiology Department, Institute for Cardiovascular Diseases Dedinje, Belgrade, Belgrade
2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Interests: heart failure; body wasting; biomarkers; metabolism; cardiac magnetic resonance

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Guest Editor
Department of Cardiology and Pneumology, University Medicine Gottingen (UMG), Gottingen, Germany
Interests: heart failure; metabolism; geriatric syndrome

Special Issue Information

Dear Colleagues,

Dietary and nutritional aspects in patients with heart failure, as well as their association with patient performance and outcome, remain underinvestigated. This issue aims to address these topics as a whole, from epidemiological, pathophysiological, management and outcome aspects. Specific emphasis will be placed on interventional studies and studies to identify achievable targets for clinical practice. Also, studies about reliable and validated tools for patient assessment are encouraged. Large-scale, preferably nationally representative epidemiological data are also of great interest for this topic.

Prof. Dr. Mitja Lainscak
Prof. Dr. Stephan Von Haehling
Dr. Goran Loncar
Dr. Ryosuke Sato
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • diet
  • appetite
  • nutrition
  • frailty
  • skeletal muscle
  • fat tissue
  • survival
  • cardiac cachexia

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Published Papers (1 paper)

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Review

17 pages, 627 KB  
Review
Sarcopenia in Chronic Heart Failure: Pathophysiology, Clinical Consequences, and Emerging Multimodal Therapeutic Strategies
by Dominik Kurczyński, Adam Załuczkowski, Helena Kalota, Brygida Przywara-Chowaniec and Andrzej Tomasik
Nutrients 2026, 18(9), 1431; https://doi.org/10.3390/nu18091431 - 30 Apr 2026
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Abstract
Sarcopenia is increasingly recognized as a key extracardiac manifestation of heart failure (HF), contributing to functional impairment, reduced quality of life, and adverse clinical outcomes. Characterized by progressive loss of skeletal muscle mass, strength, and physical performance, it affects more than half of [...] Read more.
Sarcopenia is increasingly recognized as a key extracardiac manifestation of heart failure (HF), contributing to functional impairment, reduced quality of life, and adverse clinical outcomes. Characterized by progressive loss of skeletal muscle mass, strength, and physical performance, it affects more than half of hospitalized HF patients. It is independently associated with increased mortality and reduced exercise capacity. The pathophysiology of sarcopenia in HF is multifactorial and closely linked to metabolic and nutritional disturbances. Chronic inflammation, neurohormonal activation, oxidative stress, endothelial dysfunction, and anabolic resistance contribute to muscle catabolism and impaired protein synthesis. These alterations are further exacerbated by inadequate dietary protein intake and micronutrient deficiencies, promoting progressive muscle wasting and functional decline. Sarcopenia may also represent an early and potentially modifiable stage in the continuum toward cardiac cachexia. This narrative review provides a comprehensive synthesis of current evidence on the epidemiology, pathophysiological mechanisms, and management of sarcopenia in HF, with particular emphasis on nutritional and metabolic determinants. Emerging data support a multimodal therapeutic approach integrating exercise training with targeted nutritional strategies, including adequate protein intake, essential amino acid supplementation, and correction of micronutrient deficiencies. However, evidence from large, well-designed trials remains limited. In summary, improved recognition and integrated management of sarcopenia in HF are essential. Future research should focus on the development of effective, nutrition-centered therapeutic strategies. Full article
(This article belongs to the Special Issue Diet, Nutrition and Body Tissues in Patients with Heart Failure)
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