Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.1
5.0
Journals
Nutrients
Special Issues
Nutritional Intervention and Clinical Management for Musculoskeletal Diseases
nutrients-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Nutritional Intervention and Clinical Management for Musculoskeletal Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 15 April 2026 | Viewed by 928

Special Issue Editors

Dr. Ioannis Kanakis

E-Mail Website
Guest Editor
Chester Medical School, Faculty of Health, Medicine and Society, University of Chester, Chester CH1 4BJ, UK
Interests: musculoskeletal biology; extracellular matrix; clinical biochemistry; diabetes; microRNAs
Dr. Ioanna Myrtziou

E-Mail Website
Guest Editor
Chester Medical School, Faculty of Health, Medicine and Society, University of Chester, Chester CH1 4BJ, UK
Interests: redox biology; epigenetics; musculoskeletal physiology; diabetes; metabolism; biochemistry

Special Issue Information

Dear Colleagues,

Musculoskeletal (MSK) diseases encompass a wide range of conditions that affect the bones, joints, muscles, and connective tissues, including osteoporosis, osteoarthritis, rheumatoid arthritis, and sarcopenia. These conditions are leading causes of disability and reduced quality of life worldwide, particularly among aging populations with great impacts on health and social care. While genetic, environmental, and lifestyle factors contribute to the development and progression of MSK diseases, nutrition also plays a critical role, offering a proactive approach in prevention and management. Nutritional interventions aim to provide the essential nutrients required for maintaining MSK health, reducing inflammation, and supporting tissue repair and regeneration. In addition, personalized guidance from healthcare professionals is essential to optimize nutritional strategies and achieve the best possible outcomes.

This Special Issue aims to focus on new insights, novel dietary approaches, current challenges, and future perspectives in the field of nutritional interventions for musculoskeletal diseases and provide a comprehensive update.

We invite basic, clinical, and translational researchers in relevant fields to submit original research articles, literature/narrative reviews, systematic reviews, and hypothesis-driven papers addressing important issues such as, but not limited to, the following:

  • New advances in understanding how nutrients control molecular and cellular homeostasis.
  • How nutritional interventions and nutrients affect the MSK (patho)physiology in animal and in vitro models.
  • Clinical nutritional management of MSK disorders.

Dr. Ioannis Kanakis
Dr. Ioanna Myrtziou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • osteoporosis
  • osteoarthritis
  • sarcopenia
  • nutrients
  • clinical management
  • dietary interventions

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Other

25 pages, 2319 KB  
Systematic Review
Impact of Dietary Patterns on Skeletal Health: A Systematic Review and Meta-Analysis of Bone Mineral Density, Fracture, Bone Turnover Markers, and Nutritional Status
by Adhithya Mullath Ullas, Joseph Boamah, Amir Hussain, Ioanna Myrtziou and Ioannis Kanakis
Nutrients 2025, 17(24), 3845; https://doi.org/10.3390/nu17243845 - 9 Dec 2025
Viewed by 546
Abstract
Background/Objectives: Dietary patterns play a crucial role in musculoskeletal health; however, the effects of different diets on bone mineral density (BMD), fracture risk, and bone metabolism remain inconsistent across studies. This systematic review and meta-analysis aimed to evaluate the impact of Mediterranean, calorie [...] Read more.
Background/Objectives: Dietary patterns play a crucial role in musculoskeletal health; however, the effects of different diets on bone mineral density (BMD), fracture risk, and bone metabolism remain inconsistent across studies. This systematic review and meta-analysis aimed to evaluate the impact of Mediterranean, calorie restriction, high-protein, low-carbohydrate, and ketogenic diets on skeletal outcomes in adults. Methods: A comprehensive search of PubMed/MEDLINE, CENTRAL, and Web of Science was conducted for studies published between January 2000 and June 2025. Eligible randomised controlled trials (RCTs) and cohort studies involving adults (≥18 years) and reporting outcomes related to BMD, fractures, bone turnover markers, and vitamin D or calcium status were included. Risk of bias was assessed using the Cochrane’s Risk of Bias tool for RCTs and the Joanna Briggs Institute checklist for observational studies. Random-effects meta-analyses were performed for outcomes reported by ≥3 comparable studies, presenting standardised mean differences (SMDs) for BMD and hazard ratios (HRs) for fractures. Results: Thirty studies met inclusion criteria, comprising 14 RCTs and 16 observational studies with over 500,000 participants. Pooled analyses showed no significant differences in BMD at the femoral neck (SMD = 0.12, 95% CI −0.80 to 1.04), lumbar spine (SMD = 0.04, 95% CI: −1.12 to 1.03), total hip (SMD = −0.07, 95% CI −0.36 to 0.21), or whole body (SMD = 0.03, 95% CI −0.07 to 0.14) across diet categories. However, adherence to a Mediterranean diet was associated with a significantly reduced hazard of hip and overall fractures (pooled HR = 0.95, 95% CI 0.93–0.96). Calorie restriction consistently increased bone resorption markers, whereas Mediterranean and high-protein diets showed neutral or modestly favourable effects. Vitamin D and calcium status were minimally affected across interventions. Conclusions: While dietary patterns exert diverse effects on skeletal health, consistent evidence supports Mediterranean-style diets as protective against fractures. Calorie restriction may elevate bone turnover, whereas ketogenic and high-protein diets show mixed effects on bone. However, across all analyses, high heterogeneity was observed. Further high-quality RCTs are warranted to clarify these relationships and inform dietary guidance for bone health. Full article
(This article belongs to the Special Issue Nutritional Intervention and Clinical Management for Musculoskeletal Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop