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Effects of Diet Balance and Nutrition on Metabolic Bone Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (1 July 2022) | Viewed by 2540

Special Issue Editors

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Guest Editor
Centre of Rheumatic Diseases, King's College London, London, UK
Interests: epidemiology; patient-reported outcomes; inflammatory arthritis; multimorbiditymedical educationinflammation and nutrition; self-management of disease
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, 1700 Nicosia, Cyprus
Interests: Mediterranean diet; glycaemic index; chrononutrition; rheumatoid arthritis; cognitive function; cardiometaboic health; bone disease

Special Issue Information

Dear Colleagues,

There has been accumulating evidence and increasing recognition in the contribution of diet in metabolic bone disease with both macro- and micronutrients as well as dietary patterns playing important roles in bone health.  Metabolic bone disease is an umbrella term encompassing conditions like osteopenia, osteoporosis, osteomalacia and rickets, all which if left untreated can lead to bone fragility and reduced quality of life.   In recent years, research has focused on the potential role of nutritional biomarkers and their impact on metabolic bone health and endocrine pathways.  Aside from nutrition, other lifestyle factors such as exercise, smoking, alcohol and sleep, also play critical roles in bone health.  In an era of an ageing population and accumulating comorbidities and frailty, nutrition, and general lifestyle advice in the context of bone health, gain particular relevance as part of a holistic patient management. In this Special Issue of Nutrients, we hope to improve the understanding of the role of specific nutrients and diet as a whole on bone health.  We invite papers that address topics ranging from the role of nutrition in mechanistic processes relevant to bone health through to nutritional recommendations aiming to improve the disease course and the management of bone disease.

Dr. Elena Nikiphorou
Dr. Elena Philippou
Guest Editors

Manuscript Submission Information

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  • Metabolic bone disease
  • Dietary patterns
  • Nutrients
  • Lifestyle

Published Papers (1 paper)

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10 pages, 2525 KiB  
The Positive Association of Plasma Levels of Vitamin C and Inverse Association of VCAM-1 and Total Adiponectin with Bone Mineral Density in Subjects with Diabetes
by Sushil K. Jain, William E. McLean, Christopher M. Stevens and Richa Dhawan
Nutrients 2022, 14(19), 3893; - 20 Sep 2022
Cited by 4 | Viewed by 1895
Context. Population studies have shown a trend in decreasing vitamin C status and increasing prevalence of osteoporosis in patients with diabetes and non-diabetic people. Dietary vitamin C consumption is linked to improvement in bone mineral density (BMD) in epidemiological studies. VCAM-1 and adiponectin [...] Read more.
Context. Population studies have shown a trend in decreasing vitamin C status and increasing prevalence of osteoporosis in patients with diabetes and non-diabetic people. Dietary vitamin C consumption is linked to improvement in bone mineral density (BMD) in epidemiological studies. VCAM-1 and adiponectin are known to activate osteoclasts, which increase bone loss. Aim: This study examined whether there is any association between the circulating level of vitamin C and BMD and whether the beneficial effect of vitamin C on BMD was linked to a simultaneous decrease in circulating levels of adiponectin and VCAM-1 in subjects with diabetes. Methods: Patients with diabetes (T2D, n = 74) and age-matched non-diabetic controls (n = 26) were enrolled in this study. Fasting blood levels of glycemia, adiponectin, VCAM-1, inflammation biomarkers, and vitamin C were determined in both groups. The BMD of the lumbar spine (L1–L4), left femur, and right femur was determined using a DXA scan in subjects with diabetes. Results: Patients with diabetes had lower levels of vitamin C and higher levels of VCAM-1 and inflammatory cytokines. There was a significant positive association between vitamin C blood levels and lumbar spine BMD as well as a significant negative association between total adiponectin and VCAM-1 levels with that of vitamin C and lumbar BMD in patients with diabetes. Total adiponectin and VCAM-1 also showed a negative association with BMD of both the right and left femurs. The inter-relationship among the circulating levels of vitamin C and VCAM-1 and BMD was strong and is a novel finding. Conclusions: This study reports a positive association of circulating vitamin C levels and the BMD and that the beneficial effects of vitamin C on BMD could be linked to a simultaneous lowering in circulating VCAM-1 and total adiponectin levels. Thus, dietary vitamin C consumption has potential to lower inflammation and the risk of osteoporosis in subjects with diabetes. Full article
(This article belongs to the Special Issue Effects of Diet Balance and Nutrition on Metabolic Bone Disease)
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